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Study · In vitro (cells) · rat and mouse · 2002

3 results

A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.

Caricasole A, Bruno V, Cappuccio I, Melchiorri D, Copani A, Nicoletti F

FASEB journal : official publication of the Federation of American Societies for Experimental Biology21 Jun 2002Cited by 51 (Europe PMC)

PMID12154011 (opens in a new tab)DOI10.1096/fj.02-0018fje (opens in a new tab)PepBankPUB-12154011
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In rat and mouse cultured cortical neurons, Humanin protected against Abeta-induced toxicity, as effectively as the full-length Rattin peptide and its 1-25 fragment.

    In plain wordsIn cells, humanin protected rat and mouse brain neurons from amyloid-beta toxicity about as well as a rat humanin-like peptide.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta-induced toxicity in cortical neurons
    Study

    rat, mousen: not reported in source

    cultured cortical neurons
    Comparator
    Rattin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The full-length Rattin peptide and its 1-25 fragment were equally effective as Humanin in protecting rat- and mouse-cultured cortical neurons against Ab-induced toxicity.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured neurons, Humanin was much less effective than Rattin against excitotoxic neuronal death induced by a toxic pulse with NMDA.

    In plain wordsIn cells, humanin was much less effective than a rat humanin-like peptide against nerve cell death caused by NMDA.

    Peptide
    Humanin
    Outcome
    Direction not reportedNMDA-induced excitotoxic neuronal death
    Study

    n: not reported in source

    cultured neurons
    Comparator
    Rattin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, Rattin was much more effective than Humanin against excitotoxic neuronal death induced by a toxic pulse with NMDA.
  3. 03LabIn vitro (cells)Activity measurement

    Humanin did not affect neuronal apoptosis induced by trophic deprivation in cultured cerebellar granule cells depleted of extracellular potassium.

    In plain wordsIn cells, humanin did not change nerve cell death caused by loss of growth support in cultured cerebellar neurons.

    Peptide
    Humanin
    Outcome
    No significant changeTrophic deprivation-induced apoptosis in cerebellar granule cells
    Study

    n: not reported in source

    cultured cerebellar granule cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither Rattin not Humanin could affect neuronal apoptosis by trophic deprivation induced in cultured cerebellar granule cells depleted of extracellular potassium.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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