Gonadotropin release in periovulatory heifers after GnRH analogs measured by two types of immunoassays.

Schneider F, Bellmann A, Becker F, Bambang Poernomo S, Rehfeldt C, Nürnberg G, Kanitz W

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association1 Aug 2002Cited by 19 (Europe PMC)

PMID12148088DOI10.1055/s-2002-33073PepBankPUB-12148088

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In periovulatory heifers, triptorelin induced an initial increase in LH concentration before later suppression.
In plain wordsIn cattle, triptorelin initially increased LH concentrations before later suppression.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseInitial LH concentration
Study
Cattlen: not reported in source
Periovulatory heifers
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 mg per injection, six injectionsAs given in this study (Cattle).
Source sentences
Summary
On the contrary, prior to suppression of LH levels due to down-regulation of pituitary GnRH receptors the agonist Triptorelin induced an initial increase in LH concentration which was followed by ovulation.
2 context sentences(design, population, supporting numbers)
Summary · context
This study on heifers (n = 27) compared the effects of a GnRH antagonist (Antarelix) and those of an agonist (Triptorelin) on gonadotropin release during the periovulatory period of the oestrous cycle.
Summary · context
In EXP I (n = 9), heifers received six times 1.5 mg of Antarelix, 0.5 mg of Triptorelin, and mannitol (5%; control), respectively.
Report a problemFND-1214808801
02AnimalAnimal study (in vivo)Mechanism
In periovulatory heifers, triptorelin suppressed LH levels after the initial increase, through pituitary GnRH receptor down-regulation.
In plain wordsIn cattle, triptorelin lowered LH levels after an initial increase.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSubsequent LH suppression
Study
Cattlen: not reported in source
Periovulatory heifers
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 mg per injection, six injectionsAs given in this study (Cattle).
Source sentences
Summary
On the contrary, prior to suppression of LH levels due to down-regulation of pituitary GnRH receptors the agonist Triptorelin induced an initial increase in LH concentration which was followed by ovulation.
2 context sentences(design, population, supporting numbers)
Summary · context
This study on heifers (n = 27) compared the effects of a GnRH antagonist (Antarelix) and those of an agonist (Triptorelin) on gonadotropin release during the periovulatory period of the oestrous cycle.
Summary · context
In EXP I (n = 9), heifers received six times 1.5 mg of Antarelix, 0.5 mg of Triptorelin, and mannitol (5%; control), respectively.
Report a problemFND-1214808802
03AnimalAnimal study (in vivo)Mechanism
In periovulatory heifers, ovulation followed the initial LH increase induced by triptorelin.
In plain wordsIn cattle, ovulation followed the initial LH increase after triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableOvulation after initial LH increase
Study
Cattlen: not reported in source
Periovulatory heifers
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 mg per injection, six injectionsAs given in this study (Cattle).
Source sentences
Summary
On the contrary, prior to suppression of LH levels due to down-regulation of pituitary GnRH receptors the agonist Triptorelin induced an initial increase in LH concentration which was followed by ovulation.
2 context sentences(design, population, supporting numbers)
Summary · context
This study on heifers (n = 27) compared the effects of a GnRH antagonist (Antarelix) and those of an agonist (Triptorelin) on gonadotropin release during the periovulatory period of the oestrous cycle.
Summary · context
In EXP I (n = 9), heifers received six times 1.5 mg of Antarelix, 0.5 mg of Triptorelin, and mannitol (5%; control), respectively.
Report a problemFND-1214808803
04AnimalAnimal study (in vivo)Mechanism
In periovulatory heifers previously treated with triptorelin, Gonavet challenge did not produce an LH increase.
In plain wordsIn cattle previously given triptorelin, LH did not increase after a Gonavet challenge.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLH response to Gonavet challenge
Study
Cattlen: not reported in source
Periovulatory heifers
Comparator
Before Gonavet challenge
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 mg per injection, six injectionsAs given in this study (Cattle).
Source sentences
Summary
An increase was also observed in antagonist, but not in Triptorelin treated heifers.
4 context sentences(design, population, supporting numbers)
Summary · context
In the control animals we observed endogenous LH surges as well as smaller elevations after the agonist (Gonavet) challenge.
Summary · context
A challenge by a GnRH agonist (Gonavet) was performed six hours after the last application of analogs.
Summary · context
This study on heifers (n = 27) compared the effects of a GnRH antagonist (Antarelix) and those of an agonist (Triptorelin) on gonadotropin release during the periovulatory period of the oestrous cycle.
Summary · context
In EXP I (n = 9), heifers received six times 1.5 mg of Antarelix, 0.5 mg of Triptorelin, and mannitol (5%; control), respectively.
Report a problemFND-1214808804
05AnimalAnimal study (in vivo)Mechanism
In periovulatory heifers treated with triptorelin, pituitary GnRH receptors were undetectable, while receptors were measurable in controls.
In plain wordsIn cattle, pituitary GnRH receptors were undetectable after triptorelin treatment, compared with measurable receptors in controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDetectable pituitary GnRH receptors
Study
Cattlen: not reported in source
Periovulatory heifers
Comparator
Mannitol controls
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.5 mg per injection, six injectionsAs given in this study (Cattle).
Source sentences
Summary
Pituitary GnRH receptors were not detectable in animals previously treated by the analogs, whereas concentrations between 2.2-21.0 fmol/mg protein were measured in controls.
2 context sentences(design, population, supporting numbers)
Summary · context
This study on heifers (n = 27) compared the effects of a GnRH antagonist (Antarelix) and those of an agonist (Triptorelin) on gonadotropin release during the periovulatory period of the oestrous cycle.
Summary · context
In EXP I (n = 9), heifers received six times 1.5 mg of Antarelix, 0.5 mg of Triptorelin, and mannitol (5%; control), respectively.
Report a problemFND-1214808805

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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