Pulsatile leptin secretion is independent of luteinizing hormone secretion in prepubertal sheep.

Recabarren SE, Lobos A, Vilches C, Muñoz P, Sir-Petermann T

Endocrine1 Apr 2002Cited by 8 (Europe PMC)

PMID12108517DOI10.1385/endo:17:3:175PepBankPUB-12108517

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ewe lambs, triptorelin reduced LH secretion versus vehicle controls at 26 and 30 weeks of age.
In plain wordsIn sheep, triptorelin-treated lambs had lower LH secretion than vehicle-treated lambs at the later measurements.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH secretion at later ages
Study
Sheepn = 11
Prepubertal Suffolk ewe lambs
Comparator
Vehicle-treated lambs
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In LHRH agonist-treated lambs, LH secretion diminished from 20 to 30 wk of age and was lower than in control lambs at 26 and 30 wk of age (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851702
02AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ewe lambs, leptin secretion parameters did not differ between daytime and nighttime in either triptorelin-treated or control groups.
In plain wordsIn sheep, leptin secretion measures were similar during daytime and nighttime in both triptorelin-treated and control lambs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeDiurnal versus nocturnal leptin secretion parameters
Study
Sheepn = 11
Prepubertal Suffolk ewe lambs
Comparator
Nocturnal measurements
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
There were no differences between diurnal and nocturnal parameters of leptin secretion in both groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851707
03AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ewe lambs given triptorelin, LH secretion diminished from 20 to 30 weeks of age.
In plain wordsIn sheep, LH secretion decreased with age in triptorelin-treated lambs compared with their initial measurement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH secretion over age
Study
Sheepn = 5
Prepubertal Suffolk ewe lambs
Comparator
20 weeks of age
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In LHRH agonist-treated lambs, LH secretion diminished from 20 to 30 wk of age and was lower than in control lambs at 26 and 30 wk of age (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851701
04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In ewe lambs given triptorelin, mean plasma leptin concentrations did not decrease with age.
In plain wordsIn sheep, mean plasma leptin did not decrease with age in triptorelin-treated lambs compared with earlier measurements.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedMean plasma leptin concentration
Study
Sheepn = 5
Prepubertal Suffolk ewe lambs
Comparator
Earlier measurement
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Contrary to the findings in LH secretion, in LHRH agonist-treated lambs, mean plasma leptin concentrations did not decrease.
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851703
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-treated ewe lambs, mean diurnal leptin concentrations were higher at 26 and 30 weeks than at 20 weeks.
In plain wordsIn sheep, daytime leptin concentrations were higher at later measurements than initially in triptorelin-treated lambs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseMean diurnal leptin concentration
Study
Sheepn = 5
Prepubertal Suffolk ewe lambs
Comparator
20 weeks of age
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Furthermore, the mean diurnal and nocturnal leptin concentrations and the pulse amplitude were higher at 26 and 30 wk than at 20 wk in LHRH agonist-treated lambs (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851704
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-treated ewe lambs, mean nocturnal leptin concentrations were higher at 26 and 30 weeks than at 20 weeks.
In plain wordsIn sheep, nighttime leptin concentrations were higher at later measurements than initially in triptorelin-treated lambs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseMean nocturnal leptin concentration
Study
Sheepn = 5
Prepubertal Suffolk ewe lambs
Comparator
20 weeks of age
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Furthermore, the mean diurnal and nocturnal leptin concentrations and the pulse amplitude were higher at 26 and 30 wk than at 20 wk in LHRH agonist-treated lambs (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851705
07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-treated ewe lambs, leptin pulse amplitude was higher at 26 and 30 weeks than at 20 weeks.
In plain wordsIn sheep, leptin pulse size was higher at later measurements than initially in triptorelin-treated lambs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLeptin pulse amplitude
Study
Sheepn = 5
Prepubertal Suffolk ewe lambs
Comparator
20 weeks of age
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Furthermore, the mean diurnal and nocturnal leptin concentrations and the pulse amplitude were higher at 26 and 30 wk than at 20 wk in LHRH agonist-treated lambs (p < 0.05).
3 context sentences(design, population, supporting numbers)
Summary · context
Spring-born 20-wk-old Suffolk ewe lambs (n = 5) received intramuscularly a long-acting LHRH agonist (Decapeptyl).
Summary · context
Treatment was repeated at 24 and 28 wk of age.
Summary · context
Control lambs (n = 6) received the vehicle of Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1210851706

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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