Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults.

Tajima H, Niikura T, Hashimoto Y, Ito Y, Kita Y, Terashita K, Yamazaki K, Koto A, Aiso S, Nishimoto I

Neuroscience letters1 May 2002Cited by 117 (Europe PMC)

PMID12009529DOI10.1016/s0304-3940(02)00199-4PepBankPUB-12009529

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
HN immunoreactivity was detected in an Alzheimer's disease brain but little in normal brains.
In plain wordsThe body's own humanin was found in an Alzheimer's disease brain but only a little in normal brains.
Peptide
Humanin
Outcome
IncreaseHN immunoreactivity in Alzheimer's disease brain
Study
n: not reported in source
Comparator
Normal brains
Outcome group
Endogenous peptide levels · Nervous system and cognition
Source sentences
Summary
HN immunoreactivity was also detected in an AD brain, but little in normal brains.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1200952903
02AnimalEndogenous levelAnimal study (in vivo)Other
Immunoblot analysis detected a 3-kDa protein with HN immunoreactivity in the testis and colon of 3-week-old mice and in the testis of 12-week-old mice.
In plain wordsIn mice, the body's own humanin was detected in the testis and colon of young mice and in the testis of older mice.
Peptide
Humanin
Outcome
Not applicableHN immunoreactivity in mouse tissues
Study
mousen: not reported in source
testis and colon tissue
Outcome group
Endogenous peptide levels · Whole body
Source sentences
Summary
Immunoblot analysis detected a 3-kDa protein with HN immunoreactivity in the testis and the colon in 3-week-old mice and in the testis in 12-week-old mice.
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-1200952902

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

03LabNot a test of Humanin aloneIn vitro (cells)Mechanism
Long cDNAs containing the Humanin open reading frame produced the Humanin peptide in mammalian cells, dependent on the full-length open reading frame.
In plain wordsIn cells, long gene sequences that contain the humanin code made the humanin peptide.
Peptide
Humanin
Outcome
Not applicableHN peptide production from HN-ORF cDNA
Study
n: not reported in source
mammalian cells
Outcome group
Endogenous peptide levels · Pharmacology
Source sentences
Summary
Here, we raised anti-HN antibody and found that long cDNAs containing the ORF of HN (HN-ORF) produced the HN peptide in mammalian cells, dependent on the presence of full-length HN-ORF.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-1200952901

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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