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Study · In vitro (cell-free) · 2002

5 results

Thymosin beta4 is released from human blood platelets and attached by factor XIIIa (transglutaminase) to fibrin and collagen.

Huff T, Otto AM, Müller CS, Meier M, Hannappel E

FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 May 2002Cited by 64 (Europe PMC)

PMID11978733 (opens in a new tab)DOI10.1096/fj.01-0713com (opens in a new tab)PepBankPUB-11978733
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In cell-free assays, thymosin beta4 was cross-linked to proteins such as fibrin and collagen by tissue transglutaminase.

    In plain wordsIn lab tests, an enzyme attached thymosin beta4 to fibrin and collagen.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCross-linking to fibrin and collagen
    Study

    n: not reported in source

    Purified proteins with tissue transglutaminase
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that thymosin beta4 can be cross-linked to proteins such as fibrin and collagen by tissue transglutaminase.
  2. 02LabIn vitro (cell-free)Mechanism

    In cell-free assays, thymosin beta4 was not cross-linked to many other proteins.

    In plain wordsIn lab tests, thymosin beta4 was attached to only some proteins and not to many others.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCross-linking specificity
    Study

    n: not reported in source

    Purified proteins with tissue transglutaminase
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta4 is not cross-linked to many other proteins and its cross-linking to fibrin is competed by another family member, thymosin beta10.
  3. 03LabIn vitro (cell-free)Mechanism

    In cell-free assays, cross-linking of thymosin beta4 to fibrin was competed by thymosin beta10.

    In plain wordsIn lab tests, thymosin beta10 competed with thymosin beta4 for attachment to fibrin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCompetition by thymosin beta10 for fibrin cross-linking
    Study

    n: not reported in source

    Purified proteins with tissue transglutaminase
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin beta4 is not cross-linked to many other proteins and its cross-linking to fibrin is competed by another family member, thymosin beta10.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 04LabEndogenous levelEx vivo tissueMechanism

    After thrombin activation of human platelets, thymosin beta4 was released.

    In plain wordsIn lab tests, activated human platelets released their own thymosin beta4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseRelease of thymosin beta4 from activated platelets
    Study

    humann: not reported in source

    Thrombin-activated human platelets
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    After activation of human platelets with thrombin, thymosin beta4 is released and cross-linked to fibrin in a time- and calcium-dependent manner.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 05LabEndogenous levelEx vivo tissueMechanism

    After thrombin activation of human platelets, released thymosin beta4 was cross-linked to fibrin in a time- and calcium-dependent manner.

    In plain wordsIn lab tests, the body's own thymosin beta4 released by activated human platelets attached to fibrin over time and needed calcium.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCross-linking of released thymosin beta4 to fibrin
    Study

    humann: not reported in source

    Thrombin-activated human platelets
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    After activation of human platelets with thrombin, thymosin beta4 is released and cross-linked to fibrin in a time- and calcium-dependent manner.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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