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Study · Observational study · n = 52 · 2002

8 results

Comparison of GnRH agonists and antagonists in unselected IVF/ICSI patients treated with different controlled ovarian hyperstimulation protocols: a matched study.

Del Gadillo JC, Siebzehnrübl E, Dittrich R, Wildt L, Lang N

European journal of obstetrics, gynecology, and reproductive biology1 May 2002Cited by 14 (Europe PMC)

PMID11950487 (opens in a new tab)DOI10.1016/s0301-2115(01)00580-2 (opens in a new tab)PepBankPUB-11950487
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, serum LH remained low during stimulation with both triptorelin and cetrorelix protocols.

    In plain wordsIn matched IVF/ICSI patients, LH remained low during stimulation with both triptorelin and cetrorelix protocols.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableSerum LH during stimulation
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both groups, serum LH levels remained low during the stimulation.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  2. 02HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, stimulation duration was similar with triptorelin and cetrorelix protocols.

    In plain wordsIn matched IVF/ICSI patients, stimulation duration was similar with triptorelin and cetrorelix protocols.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeStimulation duration
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean length of stimulation, and the dose of FSH required per patient were similar in both groups.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  3. 03HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, FSH dose per patient was similar with triptorelin and cetrorelix protocols.

    In plain wordsIn matched IVF/ICSI patients, FSH dose was similar with triptorelin and cetrorelix protocols.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFSH dose per patient
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mean length of stimulation, and the dose of FSH required per patient were similar in both groups.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  4. 04HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, the triptorelin protocol was linked to higher E2 on hCG administration day than cetrorelix.

    In plain wordsIn matched IVF/ICSI patients, triptorelin was linked to higher E2 on hCG administration day than cetrorelix.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseE2 on hCG administration day
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    E2
    2076 pg/ml
    Group II triptorelin
    E2
    1145 pg/ml
    Group I cetrorelix

    Source sentences

    Summary
    The mean E2 level on day of hCG administration was significantly higher in the patients of Group II (2076+/-1430 versus 1145+/-605 pg/ml), however, a progressive increase in serum E2 concentration during the cycle was noted in both groups.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  5. 05HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, mature oocytes per patient numbered 6.34 with triptorelin and 5.38 with cetrorelix.

    In plain wordsIn matched IVF/ICSI patients, triptorelin was linked to more mature eggs per patient than cetrorelix.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseMature oocytes per patient
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Mature oocytes
    6.34 per patient
    Group II
    Mature oocytes
    5.38 per patient
    Group I

    Source sentences

    Summary
    A median of 5.38 and 6.34 mature oocytes per patient was obtained, and the fertilization rate was 59.3% in Group I and 63.6% in Group II.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  6. 06HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, fertilization rates were 63.6% with triptorelin and 59.3% with cetrorelix.

    In plain wordsIn matched IVF/ICSI patients, triptorelin was linked to a higher reported fertilization rate than cetrorelix.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseFertilization rate
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Fertilization rate
    63.6%
    Group II
    Fertilization rate
    59.3%
    Group I

    Source sentences

    Summary
    A median of 5.38 and 6.34 mature oocytes per patient was obtained, and the fertilization rate was 59.3% in Group I and 63.6% in Group II.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  7. 07HumanObservational studyEfficacy outcome

    In matched IVF/ICSI patients, the triptorelin protocol was linked to a higher pregnancy rate than cetrorelix.

    In plain wordsIn matched IVF/ICSI patients, triptorelin was linked to a higher pregnancy rate than cetrorelix.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePregnancy rate
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Pregnancy rate
    15%
    Group II
    Pregnancy rate
    5%
    Group I

    Source sentences

    Summary
    Pregnancy rate (PR) were better in Group II (15 versus 5%), and no severe or moderate ovarian hyperstimulation syndrome (OHSS) occurred.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.
  8. 08HumanObservational studySafety outcome

    In matched IVF/ICSI patients, no severe or moderate ovarian hyperstimulation syndrome occurred with triptorelin or cetrorelix protocols.

    In plain wordsIn matched IVF/ICSI patients, neither triptorelin nor cetrorelix protocols had severe or moderate ovarian hyperstimulation syndrome.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableSevere or moderate OHSS
    Study

    n = 52

    Comparator
    Cetrorelix protocol
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pregnancy rate (PR) were better in Group II (15 versus 5%), and no severe or moderate ovarian hyperstimulation syndrome (OHSS) occurred.
    2 context sentences
    Summary · context
    To evaluate the results of the use of GnRH antagonist (GnRHant) and GnRH analog (GnRHa) in two matched groups of unselected IVF/ICSI patients in a retrospective matched pair analysis.
    Summary · context
    Patients in Group II (n=26) were first desensitized with GnRHa triptorelin long protocol, which was continued during the gonadotropins treatment until the induction of ovulation.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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