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Study · Animal study (in vivo) · mouse · 2002

7 results

Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury.

Sosne G, Szliter EA, Barrett R, Kernacki KA, Kleinman H, Hazlett LD

Experimental eye research1 Feb 2002Cited by 173 (Europe PMC)

PMID11950239 (opens in a new tab)DOI10.1006/exer.2001.1125 (opens in a new tab)PepBankPUB-11950239
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with alkali-injured corneas, topical Tbeta(4) accelerated re-epithelialization at all time points compared with PBS-treated controls.

    In plain wordsIn mice with chemical corneal burns, thymosin beta‑4 eye drops healed the surface faster than PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorneal re-epithelialization
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Wound healing · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Mouse corneas topically treated with 5 microg of Tbeta(4) twice daily after alkali injury demonstrated accelerated re-epithelialization at all time points
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with alkali-injured corneas, topical Tbeta(4) decreased polymorphonuclear leukocyte infiltration at 7 days after injury compared with PBS-treated controls.

    In plain wordsIn mice with chemical corneal burns, thymosin beta‑4 reduced white blood cell entry into the cornea at 7 days compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePMN infiltration at 7 days
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    Mouse corneas topically treated with 5 microg of Tbeta(4) twice daily after alkali injury demonstrated accelerated re-epithelialization at all time points and decreased polymorphonuclear leukocyte (PMN) infiltration at 7 days post injury (p.i.) when compared to PBS-treated controls
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with alkali-injured corneas, Tbeta(4) decreased interleukin-1beta mRNA several fold from 1 to 7 days after injury versus PBS-treated corneas.

    In plain wordsIn mice with corneal burns, thymosin beta‑4 lowered interleukin-1beta messenger RNA compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseIL-1beta mRNA
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    mRNA transcript levels were decreased several fold for interleukin (IL)-lbeta, and the chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, MIP-2 and monocyte chemoattractant protein (MCP)-1 from 1 to 7 days after injury in the Tbeta(4)- vs. PBS-treated corneas
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with alkali-injured corneas, Tbeta(4) decreased MIP-1alpha mRNA several fold from 1 to 7 days after injury versus PBS-treated corneas.

    In plain wordsIn mice with corneal burns, thymosin beta‑4 lowered MIP-1alpha messenger RNA compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMIP-1alpha mRNA
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    mRNA transcript levels were decreased several fold for interleukin (IL)-lbeta, and the chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, MIP-2 and monocyte chemoattractant protein (MCP)-1 from 1 to 7 days after injury in the Tbeta(4)- vs. PBS-treated corneas
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with alkali-injured corneas, Tbeta(4) decreased MIP-1beta mRNA several fold from 1 to 7 days after injury versus PBS-treated corneas.

    In plain wordsIn mice with corneal burns, thymosin beta‑4 lowered MIP-1beta messenger RNA compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMIP-1beta mRNA
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    mRNA transcript levels were decreased several fold for interleukin (IL)-lbeta, and the chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, MIP-2 and monocyte chemoattractant protein (MCP)-1 from 1 to 7 days after injury in the Tbeta(4)- vs. PBS-treated corneas
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with alkali-injured corneas, Tbeta(4) decreased MIP-2 mRNA several fold from 1 to 7 days after injury versus PBS-treated corneas.

    In plain wordsIn mice with corneal burns, thymosin beta‑4 lowered MIP-2 messenger RNA compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMIP-2 mRNA
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    mRNA transcript levels were decreased several fold for interleukin (IL)-lbeta, and the chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, MIP-2 and monocyte chemoattractant protein (MCP)-1 from 1 to 7 days after injury in the Tbeta(4)- vs. PBS-treated corneas
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with alkali-injured corneas, Tbeta(4) decreased MCP-1 mRNA several fold from 1 to 7 days after injury versus PBS-treated corneas.

    In plain wordsIn mice with corneal burns, thymosin beta‑4 lowered MCP-1 messenger RNA compared with PBS.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMCP-1 mRNA
    Study

    mousen: not reported in source

    Alkali-injured cornea
    Comparator
    PBS-treated controls
    Outcome group
    Inflammation markers · Eye
    Studied dose
    5 microg twice daily · topicalAs given in this study (mouse).

    Source sentences

    Summary
    mRNA transcript levels were decreased several fold for interleukin (IL)-lbeta, and the chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, MIP-2 and monocyte chemoattractant protein (MCP)-1 from 1 to 7 days after injury in the Tbeta(4)- vs. PBS-treated corneas
    2 context sentences
    Summary · context
    Corneas from 129 Sv mice were chemically burned with a 2 mm disc soaked in 1 N NaOH for 30 sec.
    Summary · context
    Eyes were irrigated copiously with phosphate buffered saline (PBS) and then treated topically with either Tbeta(4) (5 microg/5 microl PBS) or 5 microl PBS twice daily.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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