In nondiabetic and type 2 diabetic subjects, exendin‑4 potentiated plasma insulin responses 4- to 5-fold.
In plain wordsIn nondiabetic and type 2 diabetic subjects, insulin responses increased after exendin‑4 infusion began.
- Peptide
- Exenatide (exendin-4)
- Outcome
- IncreaseInsulin response
- Study
n: not reported in source
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- 0.15 pmol/kg/min · infusion · second hour of the clampAs given in this study (human).
Measurements
- Potentiation of plasma insulin response
- 4 to 5 fold
- nondiabetic and type 2 diabetic subjects
Source sentences
With the initiation of exendin-4 infusion at 60 min, plasma insulin response was potentiated 4- to 5-fold in both groups.
2 context sentences(design, population, supporting numbers)
In one protocol, we infused exendin-4 (0.15 pmol x kg(-1) x min(-1)) in seven nondiabetic and seven type 2 diabetic subjects during the second hour of a 5-h hyperglycemic clamp in which fasting plasma glucose was raised by 5.4 mmol/liter.
The second protocol was identical to the first except that plasma glucose was allowed to fall to the fasting levels during the fourth hour and again raised by 5.4 mmol/liter during the fifth hour in four nondiabetic and four diabetic subjects.