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Study · Non-randomized trial · n = 6 · 2002

18 results

Impact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans.

Maccario M, Veldhuis JD, Broglio F, Vito LD, Arvat E, Deghenghi R, Ghigo E

European journal of endocrinology1 Mar 2002Cited by 5 (Europe PMC)

PMID11888836 (opens in a new tab)DOI10.1530/eje.0.1460310 (opens in a new tab)PepBankPUB-11888836
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

18 results from studies that gave the peptide. 18 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six healthy young men, two or three daily hexarelin injections increased mean and 24-h integrated serum GH to the same extent.

    In plain wordsIn six healthy young men, two or three daily hexarelin injections raised growth hormone levels by the same amount.

    Peptide
    Hexarelin
    Outcome
    IncreaseMean and 24-h integrated serum GH
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Mean and integrated (24-h) serum GH concentrations were increased from baseline values to the same extent by two and three HEX injections.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  2. 02HumanNon-randomized trialEfficacy outcome

    In six healthy young men, both hexarelin schedules equally increased GH secretory burst mass.

    In plain wordsIn six healthy young men, hexarelin injections increased the amount of growth hormone released in each burst.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH secretory burst mass
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Both HEX schedules equally increased GH secretory burst mass (but not burst frequency), mean daily GH production rate, GH half-life and irregularity of GH release patterns.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  3. 03HumanNon-randomized trialEfficacy outcome

    In six healthy young men, hexarelin did not increase GH secretory burst frequency.

    In plain wordsIn six healthy young men, hexarelin did not change how often growth hormone bursts occurred.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH secretory burst frequency
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Both HEX schedules equally increased GH secretory burst mass (but not burst frequency), mean daily GH production rate, GH half-life and irregularity of GH release patterns.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  4. 04HumanNon-randomized trialEfficacy outcome

    In six healthy young men, both hexarelin schedules equally increased the mean daily GH production rate.

    In plain wordsIn six healthy young men, hexarelin injections raised daily growth hormone production.

    Peptide
    Hexarelin
    Outcome
    IncreaseMean daily GH production rate
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Both HEX schedules equally increased GH secretory burst mass (but not burst frequency), mean daily GH production rate, GH half-life and irregularity of GH release patterns.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  5. 05HumanNon-randomized trialEfficacy outcome

    In six healthy young men, both hexarelin schedules equally increased GH half-life.

    In plain wordsIn six healthy young men, hexarelin injections lengthened the time growth hormone stayed in the blood.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH half-life
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Both HEX schedules equally increased GH secretory burst mass (but not burst frequency), mean daily GH production rate, GH half-life and irregularity of GH release patterns.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  6. 06HumanNon-randomized trialEfficacy outcome

    In six healthy young men, both hexarelin schedules equally increased the irregularity of GH release patterns.

    In plain wordsIn six healthy young men, hexarelin injections made growth hormone release less regular.

    Peptide
    Hexarelin
    Outcome
    IncreaseIrregularity of GH release patterns
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Both HEX schedules equally increased GH secretory burst mass (but not burst frequency), mean daily GH production rate, GH half-life and irregularity of GH release patterns.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  7. 07HumanNon-randomized trialEfficacy outcome

    In six healthy young men, two or three daily hexarelin injections did not change IGF-I.

    In plain wordsIn six healthy young men, hexarelin injections did not change IGF-I levels.

    Peptide
    Hexarelin
    Outcome
    No significant changeIGF-I secretion
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    No change occurred in the secretion of IGF-I, PRL, ACTH and cortisol.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  8. 08HumanNon-randomized trialEfficacy outcome

    In six healthy young men, two or three daily hexarelin injections did not change prolactin secretion.

    In plain wordsIn six healthy young men, hexarelin injections did not change prolactin release.

    Peptide
    Hexarelin
    Outcome
    No significant changeProlactin secretion
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    No change occurred in the secretion of IGF-I, PRL, ACTH and cortisol.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  9. 09HumanNon-randomized trialEfficacy outcome

    In six healthy young men, two or three daily hexarelin injections did not change ACTH secretion.

    In plain wordsIn six healthy young men, hexarelin injections did not change ACTH release.

    Peptide
    Hexarelin
    Outcome
    No significant changeACTH secretion
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    No change occurred in the secretion of IGF-I, PRL, ACTH and cortisol.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  10. 10HumanNon-randomized trialEfficacy outcome

    In six healthy young men, two or three daily hexarelin injections did not change cortisol secretion.

    In plain wordsIn six healthy young men, hexarelin injections did not change cortisol release.

    Peptide
    Hexarelin
    Outcome
    No significant changeCortisol secretion
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.5 microg/kg · s.c. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    No change occurred in the secretion of IGF-I, PRL, ACTH and cortisol.
    1 context sentence
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  11. 11HumanNon-randomized trialEfficacy outcome

    In six healthy young men, intravenous hexarelin at the end of each 24-h profile induced a significant rise in GH.

    In plain wordsIn six healthy young men, a hexarelin injection into a vein raised growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to intravenous hexarelin at end of 24-h profile
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Intravenous HEX at the end of each spontaneous 24-h profile induced a significant rise in GH, PRL, ACTH and cortisol.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  12. 12HumanNon-randomized trialEfficacy outcome

    In six healthy young men, intravenous hexarelin at the end of each 24-h profile induced a significant rise in prolactin.

    In plain wordsIn six healthy young men, a hexarelin injection into a vein raised prolactin.

    Peptide
    Hexarelin
    Outcome
    IncreasePRL response to intravenous hexarelin at end of 24-h profile
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Intravenous HEX at the end of each spontaneous 24-h profile induced a significant rise in GH, PRL, ACTH and cortisol.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  13. 13HumanNon-randomized trialEfficacy outcome

    In six healthy young men, intravenous hexarelin at the end of each 24-h profile induced a significant rise in ACTH.

    In plain wordsIn six healthy young men, a hexarelin injection into a vein raised ACTH.

    Peptide
    Hexarelin
    Outcome
    IncreaseACTH response to intravenous hexarelin at end of 24-h profile
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Intravenous HEX at the end of each spontaneous 24-h profile induced a significant rise in GH, PRL, ACTH and cortisol.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  14. 14HumanNon-randomized trialEfficacy outcome

    In six healthy young men, intravenous hexarelin at the end of each 24-h profile induced a significant rise in cortisol.

    In plain wordsIn six healthy young men, a hexarelin injection into a vein raised cortisol.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol response to intravenous hexarelin at end of 24-h profile
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Intravenous HEX at the end of each spontaneous 24-h profile induced a significant rise in GH, PRL, ACTH and cortisol.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  15. 15HumanNon-randomized trialEfficacy outcome

    In six healthy young men, prior hexarelin administration blunted the GH response to intravenous hexarelin.

    In plain wordsIn six healthy young men, earlier hexarelin injections weakened the growth hormone response to a new hexarelin dose.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to intravenous hexarelin after prior hexarelin
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Prior HEX administration blunted the GH response, abolished that of ACTH and cortisol and did not modify the PRL increase.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  16. 16HumanNon-randomized trialEfficacy outcome

    In six healthy young men, prior hexarelin administration abolished the ACTH response to intravenous hexarelin.

    In plain wordsIn six healthy young men, earlier hexarelin injections removed the ACTH response to a new hexarelin dose.

    Peptide
    Hexarelin
    Outcome
    DecreaseACTH response to intravenous hexarelin after prior hexarelin
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Prior HEX administration blunted the GH response, abolished that of ACTH and cortisol and did not modify the PRL increase.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  17. 17HumanNon-randomized trialEfficacy outcome

    In six healthy young men, prior hexarelin administration abolished the cortisol response to intravenous hexarelin.

    In plain wordsIn six healthy young men, earlier hexarelin injections removed the cortisol response to a new hexarelin dose.

    Peptide
    Hexarelin
    Outcome
    DecreaseCortisol response to intravenous hexarelin after prior hexarelin
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Prior HEX administration blunted the GH response, abolished that of ACTH and cortisol and did not modify the PRL increase.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.
  18. 18HumanNon-randomized trialEfficacy outcome

    In six healthy young men, prior hexarelin administration did not modify the prolactin response to intravenous hexarelin.

    In plain wordsIn six healthy young men, earlier hexarelin injections did not change the prolactin response to a new hexarelin dose.

    Peptide
    Hexarelin
    Outcome
    No significant changePRL response to intravenous hexarelin after prior hexarelin
    Study

    n = 6

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1 microg/kg · i.v. · 1 dayAs given in this study (human).

    Source sentences

    Summary
    Prior HEX administration blunted the GH response, abolished that of ACTH and cortisol and did not modify the PRL increase.
    2 context sentences
    Summary · context
    To monitor possible down-regulation, the effect of 1 microg/kg i.v. HEX at the end of each 24-h sampling period was studied.
    Summary · context
    We investigated the impact of two or three times daily s.c. administration of a short-acting peptidyl GHS, the hexapeptide HEX (1.5 microg/kg) on 24-h GH, PRL, ACTH and cortisol secretion (sampling every 20 min) in six normal young men.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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