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Study · In vitro (cells) · rat · 2002

7 results

Protective effect of L-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells.

Kang KS, Yun JW, Lee YS

Cancer letters1 Apr 2002Cited by 23 (Europe PMC)

PMID11849741 (opens in a new tab)DOI10.1016/s0304-3835(01)00821-7 (opens in a new tab)PepBankPUB-11849741
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine prevented TPA-induced DNA fragmentation.

    In plain wordsIn cells from rat liver, L‑carnosine prevented TPA-induced DNA fragmentation.

    Peptide
    L-carnosine
    Outcome
    DecreaseTPA-induced DNA fragmentation
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Cell viability and death · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    L-Carnosine prevented both TPA- and H2O2-induced DNA fragmentation, the loss of mitochondrial membrane potentials and blocked the release of cytochrome c into cytosol.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).
  2. 02LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine prevented H2O2-induced DNA fragmentation.

    In plain wordsIn cells from rat liver, L‑carnosine prevented H2O2-induced DNA fragmentation.

    Peptide
    L-carnosine
    Outcome
    DecreaseH2O2-induced DNA fragmentation
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Cell viability and death · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    L-Carnosine prevented both TPA- and H2O2-induced DNA fragmentation, the loss of mitochondrial membrane potentials and blocked the release of cytochrome c into cytosol.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).
  3. 03LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine prevented TPA-induced loss of mitochondrial membrane potential.

    In plain wordsIn cells from rat liver, L‑carnosine prevented TPA-induced loss of mitochondrial membrane potential.

    Peptide
    L-carnosine
    Outcome
    DecreaseTPA-induced mitochondrial membrane potential loss
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    L-Carnosine prevented both TPA- and H2O2-induced DNA fragmentation, the loss of mitochondrial membrane potentials and blocked the release of cytochrome c into cytosol.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).
  4. 04LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine prevented H2O2-induced loss of mitochondrial membrane potential.

    In plain wordsIn cells from rat liver, L‑carnosine prevented H2O2-induced loss of mitochondrial membrane potential.

    Peptide
    L-carnosine
    Outcome
    DecreaseH2O2-induced mitochondrial membrane potential loss
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    L-Carnosine prevented both TPA- and H2O2-induced DNA fragmentation, the loss of mitochondrial membrane potentials and blocked the release of cytochrome c into cytosol.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).
  5. 05LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine blocked TPA-induced cytochrome c release into the cytosol.

    In plain wordsIn cells from rat liver, L‑carnosine blocked TPA-induced cytochrome c release into cell fluid.

    Peptide
    L-carnosine
    Outcome
    DecreaseTPA-induced cytochrome c release
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    L-Carnosine prevented both TPA- and H2O2-induced DNA fragmentation, the loss of mitochondrial membrane potentials and blocked the release of cytochrome c into cytosol.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).
  6. 06LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine blocked H2O2-induced cytochrome c release into the cytosol.

    In plain wordsIn cells from rat liver, L‑carnosine blocked H2O2-induced cytochrome c release into cell fluid.

    Peptide
    L-carnosine
    Outcome
    DecreaseH2O2-induced cytochrome c release
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    L-Carnosine prevented both TPA- and H2O2-induced DNA fragmentation, the loss of mitochondrial membrane potentials and blocked the release of cytochrome c into cytosol.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).
  7. 07LabIn vitro (cells)Mechanism

    In WB-myc rat liver cells, L‑carnosine significantly reduced poly(ADP-ribose) polymerase cleavage.

    In plain wordsIn cells from rat liver, L‑carnosine significantly reduced poly(ADP-ribose) polymerase cleavage.

    Peptide
    L-carnosine
    Outcome
    DecreasePoly(ADP-ribose) polymerase cleavage
    Study

    ratn: not reported in source

    v-myc transformed rat liver epithelial cells (WB-myc cells)
    Outcome group
    Cell viability and death · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Subsequently, the cleavages of poly (ADP-ribose) polymerase were significantly reduced in L-carnosine-treated cells.
    1 context sentence
    Summary · context
    We investigated whether L-carnosine prevents 12-O-tetradecanoylphorbol-13-acetate (TPA)- or hydrogen peroxide (H2O2)-induced apoptosis involving mitochondria in the v-myc transformed rat liver epithelial cells (WB-myc cells).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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