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Study · In vitro (cells) · pig · 2002

2 results

Leptin regulates GH gene expression and secretion and nitric oxide production in pig pituitary cells.

Baratta M, Saleri R, Mainardi GL, Valle D, Giustina A, Tamanini C

Endocrinology1 Feb 2002Cited by 47 (Europe PMC)

PMID11796510 (opens in a new tab)DOI10.1210/endo.143.2.8653 (opens in a new tab)PepBankPUB-11796510
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In pig anterior pituitary cells, hexarelin significantly increased GH gene expression after 24 hours of treatment.

    In plain wordsIn pig pituitary cells, hexarelin raised the activity of the growth hormone gene after 24 hours.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH gene expression after 24 h
    Study

    pign: not reported in source

    primary anterior pituitary cells from adult sows
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 nM · 24 hAs given in this study (pig).

    Source sentences

    Summary
    GH gene expression was significantly increased (at least P < 0.05) by hexarelin, GHRH, and leptin (1000 and 100 nM) after 24 h of treatment.
    1 context sentence
    Summary · context
    Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with GHRH (10 nM) or hexarelin (10 nM).

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 02LabNot a test of Hexarelin aloneIn vitro (cells)Efficacy outcome

    In pig anterior pituitary cells, a significant interaction between leptin and hexarelin on GH secretion was observed when the two were used together.

    In plain wordsIn pig pituitary cells, leptin and hexarelin used together showed a significant interaction on growth hormone release.

    Peptide
    Hexarelin
    Outcome
    Direction not reportedLeptin and hexarelin interaction on GH secretion
    Study

    pign: not reported in source

    primary anterior pituitary cells from adult sows
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    a significant interaction (P < 0.002) between leptin and GHRH (P < 0.03) and between leptin and hexarelin was observed when the molecules were used in association
    1 context sentence
    Summary · context
    Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with GHRH (10 nM) or hexarelin (10 nM).

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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