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Study · Animal study (in vivo) · mouse and rat · 2001

5 results

Anxiolytic effect of BPC-157, a gastric pentadecapeptide: shock probe/burying test and light/dark test.

Sikiric P, Jelovac N, Jelovac-Gjeldum A, Dodig G, Staresinic M, Anic T, Zoricic I, Ferovic D, Aralica G, Buljat G, Prkacin I, Lovric-Bencic M and 6 more

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Separovic J, Seiwerth S, Rucman R, Petek M, Turkovic B, Ziger T

Acta pharmacologica Sinica1 Mar 2001Cited by 13 (Europe PMC)

PMID11742568 (opens in a new tab)PepBankPUB-11742568
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the shock probe test, BPC‑157 clearly reduced total burying time compared with controls, as diazepam did.

    In plain wordsIn rats, BPC‑157 reduced burying after a shock compared with controls, as diazepam did.

    Peptide
    BPC-157
    Outcome
    DecreaseTotal burying time in shock probe test
    Study

    ratn: not reported in source

    Shock probe/burying test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg/kg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Shock probe/burying test: rats treated with either diazepam or pentadecapeptide BPC-157 were much less afraid after the shock: almost not burying and the total time spent in burying was clearly less than in controls.
    1 context sentence
    Summary · context
    In shock probe/burying test, pentadecapeptide BPC-157 (10 microg/kg, 10 ng/kg, ip), diazepam (0.075, 0.0375 mg/kg, ip), and an equivolume of saline (5 mL/kg, ip) were given at 30 min prior test.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the shock probe test, the number of shocks stayed unchanged with BPC‑157, unlike with diazepam where it increased.

    In plain wordsIn rats, BPC‑157 did not change the number of shocks received, unlike diazepam, which increased it.

    Peptide
    BPC-157
    Outcome
    No significant changeNumber of shocks received in shock probe test
    Study

    ratn: not reported in source

    Shock probe/burying test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg/kg and 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    However, while in the diazepam treated rats the number of shocks received increased over control values, in pentadecapeptide BPC-157 treated groups the number of shocks remained not modified compared with the control values.
    1 context sentence
    Summary · context
    In shock probe/burying test, pentadecapeptide BPC-157 (10 microg/kg, 10 ng/kg, ip), diazepam (0.075, 0.0375 mg/kg, ip), and an equivolume of saline (5 mL/kg, ip) were given at 30 min prior test.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, behavior in the light compartment with BPC‑157 was similar to controls, unlike with diazepam.

    In plain wordsIn mice, BPC‑157 did not change behaviour in the lit area, unlike diazepam.

    Peptide
    BPC-157
    Outcome
    No significant changeLight compartment behavior in light/dark test
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg/kg and 10 ng/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Light/dark test: after exposure to the intense light, diazepam treated mice had longer latencies of crossing to the dark compartment, a greater number of crossing and a greater number of exploratory rearing, and spent longer time in the light compartment, as compared to the control mice, while BPC-1…
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 at 10 microg/kg increased the number of crossings in the dark zone, where diazepam had no change.

    In plain wordsIn mice, BPC‑157 increased crossings in the dark zone compared with controls, where diazepam did not.

    Peptide
    BPC-157
    Outcome
    IncreaseNumber of crossings in dark zone, light/dark test
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In contrast with the effect in light area, in dark zone diazepam produced no change with respect to controls, while BPC-157 (10 microg/kg) mice had a greater number of crossing and a greater number of exploratory rearing.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice in the light/dark test, BPC‑157 at 10 microg/kg increased exploratory rearing in the dark zone, where diazepam had no change.

    In plain wordsIn mice, BPC‑157 increased exploring by rearing in the dark zone compared with controls, where diazepam did not.

    Peptide
    BPC-157
    Outcome
    IncreaseNumber of exploratory rearing in dark zone, light/dark test
    Study

    mousen: not reported in source

    Light/dark test
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    10 microg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In contrast with the effect in light area, in dark zone diazepam produced no change with respect to controls, while BPC-157 (10 microg/kg) mice had a greater number of crossing and a greater number of exploratory rearing.
    1 context sentence
    Summary · context
    In light/dark test, the same dosage of diazepam, BPC-157, and saline were given at 45 min prior procedure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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