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Study · Animal study (in vivo) · mouse · 2001

2 results

[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo.

Mamiya T, Ukai M

British journal of pharmacology1 Dec 2001Cited by 98 (Europe PMC)

PMID11739234 (opens in a new tab)PMCIDPMC1572908 (opens in a new tab)DOI10.1038/sj.bjp.0704429 (opens in a new tab)PepBankPUB-11739234
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice given scopolamine, [Gly(14)]-humanin reversed the impairment of spontaneous alternation behaviour in the Y-maze.

    In plain wordsIn mice, a more potent humanin form reversed the short-term memory impairment caused by scopolamine.

    Peptide
    Humanin
    Outcome
    IncreaseSpontaneous alternation in Y-maze after scopolamine
    Study

    mousen: not reported in source

    scopolamine-induced impairment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1000 pmol per 5 microl · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    [Gly(14)]-Humanin (1000 pmol 5 microl(-1) i.c.v.) reversed the impairment without affecting the number of arm entries.
    1 context sentence
    Summary · context
    In this study, we evaluated the effects of [Gly(14)]-humanin, a more potent humanin analogue, on the scopolamine HBr (1 mg kg(-1) s.c.)-induced impairment of spontaneous alternation behaviour in the Y-maze, an index of short-term memory in mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice given scopolamine, [Gly(14)]-humanin did not change the number of arm entries in the Y-maze.

    In plain wordsIn mice, a more potent humanin form did not change how many maze arms the mice entered.

    Peptide
    Humanin
    Outcome
    No significant changeNumber of arm entries in Y-maze
    Study

    mousen: not reported in source

    scopolamine-induced impairment
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1000 pmol per 5 microl · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    reversed the impairment without affecting the number of arm entries.
    1 context sentence
    Summary · context
    In this study, we evaluated the effects of [Gly(14)]-humanin, a more potent humanin analogue, on the scopolamine HBr (1 mg kg(-1) s.c.)-induced impairment of spontaneous alternation behaviour in the Y-maze, an index of short-term memory in mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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