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Study · Animal study (in vivo) · rat · 2001

2 results

The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats.

Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society1 Oct 2001Cited by 3 (Europe PMC)

PMID11735244 (opens in a new tab)DOI10.1054/ghir.2001.0239 (opens in a new tab)PepBankPUB-11735244
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult female rats given methylprednisolone, adding Ipamorelin significantly increased the maximum tetanic tension of the calf muscles compared with methylprednisolone alone.

    In plain wordsIn rats given a glucocorticoid, adding Ipamorelin increased calf muscle strength compared with the glucocorticoid alone.

    Peptide
    Ipamorelin
    Outcome
    IncreaseMaximum tetanic tension of calf muscles
    Study

    ratn: not reported in source

    Adult female rats given methylprednisolone
    Comparator
    Methylprednisolone (glucocorticoid) alone
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    100 microg/kg three times daily · subcutaneous · 3 monthsAs given in this study (rat).

    Source sentences

    Summary
    The maximum tetanic tension was increased significantly
    2 context sentences
    Summary · context
    in animals injected with GC and GHS in combination, compared with the group injected with GC alone.
    Summary · context
    Groups of 8-month-old female rats were injected subcutaneously for 3 months with GC (methylprednisolone) 9 mg/kg/day or GHS (Ipamorelin) 100 microg/kg three times daily, or both GC and GHS in combination.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult female rats given methylprednisolone, adding Ipamorelin increased the periosteal bone formation rate four-fold compared with methylprednisolone alone.

    In plain wordsIn rats given a glucocorticoid, adding Ipamorelin increased new bone formation four-fold compared with the glucocorticoid alone.

    Peptide
    Ipamorelin
    Outcome
    IncreasePeriosteal bone formation rate
    Study

    ratn: not reported in source

    Adult female rats given methylprednisolone
    Comparator
    Methylprednisolone (glucocorticoid) alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microg/kg three times daily · subcutaneous · 3 monthsAs given in this study (rat).

    Source sentences

    Summary
    the periosteal bone formation rate increased four-fold in animals injected with GC and GHS in combination, compared with the group injected with GC alone.
    1 context sentence
    Summary · context
    Groups of 8-month-old female rats were injected subcutaneously for 3 months with GC (methylprednisolone) 9 mg/kg/day or GHS (Ipamorelin) 100 microg/kg three times daily, or both GC and GHS in combination.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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