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Study · Animal study (in vivo) · mouse · 2001

17 results

Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice.

Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, Druzijancic N, Rucman R, Petek M, Pigac B, Perovic D, Kolombo M, Kokic N and 10 more

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Mikus S, Duplancic B, Fattorini I, Turkovic B, Rotkvic I, Mise S, Prkacin I, Konjevoda P, Stambuk N, Anic T

Burns : journal of the International Society for Burn Injuries1 Dec 2001Cited by 56 (Europe PMC)

PMID11718984 (opens in a new tab)DOI10.1016/s0305-4179(01)00055-9 (opens in a new tab)PepBankPUB-11718984
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream gave less edema than no treatment.

    In plain wordsIn burned mice, BPC‑157 cream gave less swelling than no treatment.

    Peptide
    BPC-157
    Outcome
    DecreaseEdema in burn wound
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    1 context sentence
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream decreased inflammatory cell numbers compared with no treatment.

    In plain wordsIn burned mice, BPC‑157 cream lowered the number of inflammatory cells compared with no treatment.

    Peptide
    BPC-157
    Outcome
    DecreaseInflammatory cell numbers in burn wound
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    1 context sentence
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream gave less necrosis than no treatment.

    In plain wordsIn burned mice, BPC‑157 cream gave less dead tissue than no treatment.

    Peptide
    BPC-157
    Outcome
    DecreaseNecrosis in burn wound
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Less necrosis was seen with an increased number of capillaries along with an advanced formation of dermal reticulin and collagen fibers.
    2 context sentences
    Summary · context
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream increased the number of capillaries compared with no treatment.

    In plain wordsIn burned mice, BPC‑157 cream gave more small blood vessels than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseCapillary number in burn wound
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Less necrosis was seen with an increased number of capillaries along with an advanced formation of dermal reticulin and collagen fibers.
    2 context sentences
    Summary · context
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream advanced the formation of dermal reticulin fibers compared with no treatment.

    In plain wordsIn burned mice, BPC‑157 cream sped up formation of skin reticulin fibers compared with no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseDermal reticulin fiber formation
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Less necrosis was seen with an increased number of capillaries along with an advanced formation of dermal reticulin and collagen fibers.
    2 context sentences
    Summary · context
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream advanced the formation of dermal collagen fibers compared with no treatment.

    In plain wordsIn burned mice, BPC‑157 cream sped up formation of skin collagen fibers compared with no treatment.

    Peptide
    BPC-157
    Outcome
    IncreaseDermal collagen fiber formation
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Less necrosis was seen with an increased number of capillaries along with an advanced formation of dermal reticulin and collagen fibers.
    2 context sentences
    Summary · context
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream gave more preserved follicles than no treatment.

    In plain wordsIn burned mice, BPC‑157 cream kept more hair follicles than no treatment.

    Peptide
    BPC-157
    Outcome
    IncreasePreserved follicles in burn wound
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    An increased number of preserved follicles were observed.
    2 context sentences
    Summary · context
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream completely reversed the poor re-epithelization ratio seen in untreated and vehicle-treated mice two weeks after injury.

    In plain wordsIn burned mice, BPC‑157 cream restored skin regrowth that was poor with no treatment or vehicle cream.

    Peptide
    BPC-157
    Outcome
    IncreaseRe-epithelization ratio at two weeks
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls and vehicle
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Two weeks after injury, BPC 157 cream-treated mice completely reversed the otherwise poor re-epithelization ratio noted in the untreated control or mice treated with vehicle only.
    2 context sentences
    Summary · context
    Compared with untreated controls, in both experiments, in the BPC 157 cream-treated mice all parameters of burn healing were improved throughout the experiment: less edema was observed and inflammatory cell numbers decreased.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream increased the breaking strength of burned skin on tensiometry, unlike vehicle or silver sulfadiazine.

    In plain wordsIn burned mice, BPC‑157 cream made burned skin stronger, which vehicle or silver sulfadiazine did not.

    Peptide
    BPC-157
    Outcome
    IncreaseBreaking strength of burned skin
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Tensiometry investigation showed an increased breaking strength and relative elongation of burned skin, while water content in burned skin decreased.
    2 context sentences
    Summary · context
    This was, however, not the case with the vehicle or silver sulfadiazine.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream increased the relative elongation of burned skin on tensiometry, unlike vehicle or silver sulfadiazine.

    In plain wordsIn burned mice, BPC‑157 cream made burned skin stretch more, which vehicle or silver sulfadiazine did not.

    Peptide
    BPC-157
    Outcome
    IncreaseRelative elongation of burned skin
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Tensiometry investigation showed an increased breaking strength and relative elongation of burned skin, while water content in burned skin decreased.
    2 context sentences
    Summary · context
    This was, however, not the case with the vehicle or silver sulfadiazine.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 cream decreased the water content of burned skin, unlike vehicle or silver sulfadiazine.

    In plain wordsIn burned mice, BPC‑157 cream lowered water content of burned skin, which vehicle or silver sulfadiazine did not.

    Peptide
    BPC-157
    Outcome
    DecreaseWater content of burned skin
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Tensiometry investigation showed an increased breaking strength and relative elongation of burned skin, while water content in burned skin decreased.
    2 context sentences
    Summary · context
    This was, however, not the case with the vehicle or silver sulfadiazine.
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 given intraperitoneally decreased the number of inflammatory cells relative to control values.

    In plain wordsIn burned mice, BPC‑157 injected into the abdomen lowered inflammatory cells compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseInflammatory cell number, intraperitoneal BPC 157
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10 microg or 10 ng/kg · intraperitoneal · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Relative to control values, BPC 157 given i.p. decreased the number of inflammatory cells, lowered water content in burned skin, and raised breaking strength and relative elongation of burned skin during tensiometry.
    2 context sentences
    Summary · context
    the BPC 157 was applied at 10 microg or 10 ng/kg b.w. intraperitoneally (i.p.) by injection
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 given intraperitoneally lowered the water content of burned skin relative to control values.

    In plain wordsIn burned mice, BPC‑157 injected into the abdomen lowered water content of burned skin compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseWater content of burned skin, intraperitoneal BPC 157
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10 microg or 10 ng/kg · intraperitoneal · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Relative to control values, BPC 157 given i.p. decreased the number of inflammatory cells, lowered water content in burned skin, and raised breaking strength and relative elongation of burned skin during tensiometry.
    2 context sentences
    Summary · context
    the BPC 157 was applied at 10 microg or 10 ng/kg b.w. intraperitoneally (i.p.) by injection
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 given intraperitoneally raised the breaking strength of burned skin relative to control values.

    In plain wordsIn burned mice, BPC‑157 injected into the abdomen made burned skin stronger compared with controls.

    Peptide
    BPC-157
    Outcome
    IncreaseBreaking strength of burned skin, intraperitoneal BPC 157
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10 microg or 10 ng/kg · intraperitoneal · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Relative to control values, BPC 157 given i.p. decreased the number of inflammatory cells, lowered water content in burned skin, and raised breaking strength and relative elongation of burned skin during tensiometry.
    2 context sentences
    Summary · context
    the BPC 157 was applied at 10 microg or 10 ng/kg b.w. intraperitoneally (i.p.) by injection
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, BPC‑157 given intraperitoneally raised the relative elongation of burned skin relative to control values.

    In plain wordsIn burned mice, BPC‑157 injected into the abdomen made burned skin stretch more compared with controls.

    Peptide
    BPC-157
    Outcome
    IncreaseRelative elongation of burned skin, intraperitoneal BPC 157
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    10 microg or 10 ng/kg · intraperitoneal · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Relative to control values, BPC 157 given i.p. decreased the number of inflammatory cells, lowered water content in burned skin, and raised breaking strength and relative elongation of burned skin during tensiometry.
    2 context sentences
    Summary · context
    the BPC 157 was applied at 10 microg or 10 ng/kg b.w. intraperitoneally (i.p.) by injection
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, gastric lesions were attenuated by intraperitoneal BPC‑157 at either dose, while untreated mice had continuous lesions.

    In plain wordsIn burned mice, BPC‑157 injected into the abdomen reduced stomach lesions that stayed in untreated mice.

    Peptide
    BPC-157
    Outcome
    DecreaseBurn-induced gastric lesions, intraperitoneal BPC 157
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitoneal · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Through the experimental period, gastric lesions were continuously noted in all thermally injured mice left without local medication and they were consistently attenuated only by BPC 157 treatments: either given i.p. (at either dose), or given locally (at either concentration).
    2 context sentences
    Summary · context
    the BPC 157 was applied at 10 microg or 10 ng/kg b.w. intraperitoneally (i.p.) by injection
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.
  17. 17AnimalAnimal study (in vivo)Efficacy outcome

    In burned mice, gastric lesions were attenuated by topical BPC‑157 at either concentration, while untreated mice had continuous lesions.

    In plain wordsIn burned mice, BPC‑157 cream on the burn reduced stomach lesions that stayed in untreated mice.

    Peptide
    BPC-157
    Outcome
    DecreaseBurn-induced gastric lesions, topical BPC 157
    Study

    mousen: not reported in source

    Deep partial thickness burn
    Comparator
    Untreated controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    5 ng to 50 microg in 50 g cream · topical (cream) · once daily until 24 h before sacrifice, up to 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    Through the experimental period, gastric lesions were continuously noted in all thermally injured mice left without local medication and they were consistently attenuated only by BPC 157 treatments: either given i.p. (at either dose), or given locally (at either concentration).
    1 context sentence
    Summary · context
    Deep partial skin thickness burns (1.5x1.5 cm) covering 20% of total body area, were induced under anesthesia on the back of mice by controlled burning and gastric lesions were assessed 1, 2, 3, 7, 14 and 21 days following injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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