A yeast two-hybrid screen found cDNA inserts coding for thymosin beta4 among cytoskeletal partners of SV40 large T antigen, and complex formation with large T was confirmed in vitro.
In plain wordsIn lab tests, SV40 large T antigen was found to bind Tbeta4, and the binding was confirmed in vitro.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- Not applicableComplex formation of SV40 large T antigen with Tbeta4
- Study
n: not reported in source
In vitro complex formation assay- Outcome group
- Receptor activity and mechanism · Whole body
- Studied dose
- Dose not stated
Source sentences
Interestingly, the cDNA inserts of these clones coded for different components of the cytoskeleton, lamin C, laminin gamma1, thymosin beta4, and gelsolin. Complex formation between large T and these proteins was confirmed in vitro.