The effect of tourniquet application, tranexamic acid, and desmopressin on the procoagulant and fibrinolytic systems during total knee replacement.

Ellis MH, Fredman B, Zohar E, Ifrach N, Jedeikin R

Journal of clinical anesthesia1 Nov 2001Cited by 59 (Europe PMC)

PMID11704449DOI10.1016/s0952-8180(01)00319-1PepBankPUB-11704449

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanRandomized controlled trialMechanism
In knee replacement patients, fibrinogen did not differ significantly between desmopressin and saline.
In plain wordsIn knee replacement patients, fibrinogen did not differ significantly between desmopressin and saline.
Peptide
Desmopressin
Outcome
No significant changeFibrinogen
Study
n: not reported in source
Comparator
Saline
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444901
02HumanRandomized controlled trialMechanism
In knee replacement patients, fibrinogen did not differ significantly between desmopressin and tranexamic acid.
In plain wordsIn knee replacement patients, fibrinogen did not differ significantly between desmopressin and tranexamic acid.
Peptide
Desmopressin
Outcome
No significant changeFibrinogen
Study
n: not reported in source
Comparator
Tranexamic acid
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444902
03HumanRandomized controlled trialMechanism
In knee replacement patients, D-dimer did not differ significantly between desmopressin and saline.
In plain wordsIn knee replacement patients, D-dimer did not differ significantly between desmopressin and saline.
Peptide
Desmopressin
Outcome
No significant changeD-dimer
Study
n: not reported in source
Comparator
Saline
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444903
04HumanRandomized controlled trialMechanism
In knee replacement patients, D-dimer did not differ significantly between desmopressin and tranexamic acid.
In plain wordsIn knee replacement patients, D-dimer did not differ significantly between desmopressin and tranexamic acid.
Peptide
Desmopressin
Outcome
No significant changeD-dimer
Study
n: not reported in source
Comparator
Tranexamic acid
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444904
05HumanRandomized controlled trialMechanism
In knee replacement patients, plasmin antiplasmin complex did not differ significantly between desmopressin and saline.
In plain wordsIn knee replacement patients, plasmin antiplasmin complex did not differ significantly between desmopressin and saline.
Peptide
Desmopressin
Outcome
No significant changePlasmin antiplasmin complex
Study
n: not reported in source
Comparator
Saline
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444905
06HumanRandomized controlled trialMechanism
In knee replacement patients, plasmin antiplasmin complex did not differ significantly between desmopressin and tranexamic acid.
In plain wordsIn knee replacement patients, plasmin antiplasmin complex did not differ significantly between desmopressin and tranexamic acid.
Peptide
Desmopressin
Outcome
No significant changePlasmin antiplasmin complex
Study
n: not reported in source
Comparator
Tranexamic acid
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444906
07HumanRandomized controlled trialMechanism
In knee replacement patients, prothrombin fragment 1.2 did not differ significantly between desmopressin and saline.
In plain wordsIn knee replacement patients, prothrombin fragment 1.2 did not differ significantly between desmopressin and saline.
Peptide
Desmopressin
Outcome
No significant changeProthrombin fragment 1.2
Study
n: not reported in source
Comparator
Saline
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444907
08HumanRandomized controlled trialMechanism
In knee replacement patients, prothrombin fragment 1.2 did not differ significantly between desmopressin and tranexamic acid.
In plain wordsIn knee replacement patients, prothrombin fragment 1.2 did not differ significantly between desmopressin and tranexamic acid.
Peptide
Desmopressin
Outcome
No significant changeProthrombin fragment 1.2
Study
n: not reported in source
Comparator
Tranexamic acid
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
No statistically significant difference in fibrinogen, D-dimer, plasmin antiplasmin complex, or prothrombin fragment 1.2 levels was demonstrated among the groups.
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444908
09HumanRandomized controlled trialEfficacy outcome
In knee replacement patients, significantly more allogeneic blood was transfused with desmopressin than with tranexamic acid (p<0.02).
In plain wordsIn knee replacement patients, more allogeneic blood was transfused with desmopressin than with tranexamic acid.
Peptide
Desmopressin
Outcome
IncreaseAllogeneic blood transfusion
Study
n: not reported in source
Comparator
Tranexamic acid
Outcome group
Blood Transfusion · Whole body
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
Significantly more allogeneic blood was transfused in the Control and Desmopressin Groups when compared with the tranexamic acid group (p< 0.02).
3 context sentences(design, population, supporting numbers)
Summary · context
Randomized, placebo-controlled study.
Summary · context
30 ASA physical status I, II, and III patients undergoing total knee replacement.
Summary · context
Patients received either tranexamic acid, desmopressin, or an equal volume of saline, intravenously.
Report a problemFND-1170444909

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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