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Study · Non-randomized trial · n = 40 · 2001

6 results

A comparative study of the postoperative allogeneic blood-sparing effects of tranexamic acid and of desmopressin after total knee replacement.

Zohar E, Fredman B, Ellis MH, Ifrach N, Stern A, Jedeikin R

Transfusion1 Oct 2001Cited by 26 (Europe PMC)

PMID11606830 (opens in a new tab)DOI10.1046/j.1537-2995.2001.41101285.x (opens in a new tab)PepBankPUB-11606830
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialSafety outcome

    After knee replacement, no clinical signs of deep vein thrombosis occurred in either treatment group, including desmopressin.

    In plain wordsAfter knee replacement, neither group, including desmopressin, showed clinical signs of deep vein thrombosis.

    Peptide
    Desmopressin
    Outcome
    Not applicableClinical deep vein thrombosis
    Study

    n = 40

    Outcome group
    Adverse events · Whole body
    Studied dose
    0.3 mg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There were no clinical signs of deep vein thrombosis or abnormal Doppler ultrasound studies.
    2 context sentences
    Summary · context
    A prospective, single-blind study of 40 patients undergoing TKR was performed.
    Summary · context
    In the desmopressin group, desmopressin (0.3 mg/kg) and saline were administered by a similar protocol.
  2. 02HumanNon-randomized trialSafety outcome

    After knee replacement, no abnormal Doppler ultrasound studies occurred in either group, including desmopressin.

    In plain wordsAfter knee replacement, neither group, including desmopressin, had abnormal Doppler ultrasound results.

    Peptide
    Desmopressin
    Outcome
    Not applicableAbnormal Doppler ultrasound
    Study

    n = 40

    Outcome group
    Adverse events · Whole body
    Studied dose
    0.3 mg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    There were no clinical signs of deep vein thrombosis or abnormal Doppler ultrasound studies.
    2 context sentences
    Summary · context
    A prospective, single-blind study of 40 patients undergoing TKR was performed.
    Summary · context
    In the desmopressin group, desmopressin (0.3 mg/kg) and saline were administered by a similar protocol.
  3. 03HumanNon-randomized trialSafety outcome

    Among patients interviewed after knee replacement, no thromboembolic events occurred in either group, including desmopressin, at three months.

    In plain wordsAfter knee replacement, no interviewed patients in either group, including desmopressin, reported thromboembolic events at three months.

    Peptide
    Desmopressin
    Outcome
    Not applicableThromboembolic events at three months
    Study

    n = 37

    Outcome group
    Adverse events · Whole body
    Studied dose
    0.3 mg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Three months postoperatively, there were no thromboembolic events among the 37 patients interviewed.
    2 context sentences
    Summary · context
    A prospective, single-blind study of 40 patients undergoing TKR was performed.
    Summary · context
    In the desmopressin group, desmopressin (0.3 mg/kg) and saline were administered by a similar protocol.
  4. 04HumanNon-randomized trialEfficacy outcome

    After knee replacement, drain blood over the first 12 hours was higher with desmopressin (342 mL +/- 169) than tranexamic acid (162 mL +/- 129; p<0.05).

    In plain wordsAfter knee replacement, drain blood over the first 12 hours was higher with desmopressin than with tranexamic acid.

    Peptide
    Desmopressin
    Outcome
    IncreaseDrain blood accumulation
    Study

    n: not reported in source

    Comparator
    Tranexamic acid
    Outcome group
    Bleeding · Whole body
    Studied dose
    0.3 mg/kg · intravenousAs given in this study (human).

    Measurements

    Drain blood accumulation, first 12 h
    342 mL
    desmopressin
    Drain blood accumulation SD
    169 mL
    desmopressin
    Drain blood accumulation, first 12 h
    162 mL
    tranexamic acid
    Drain blood accumulation SD
    129 mL
    tranexamic acid
    P value
    < 0.05
    desmopressin versus tranexamic acid

    Source sentences

    Summary
    During the first 12 postoperative hours, blood accumulation in the surgical drain was significantly (p<0.05) lower in the TA group (162 mL +/- 129) than in the desmopressin group (342 mL +/- 169).
    2 context sentences
    Summary · context
    A prospective, single-blind study of 40 patients undergoing TKR was performed.
    Summary · context
    In the desmopressin group, desmopressin (0.3 mg/kg) and saline were administered by a similar protocol.
  5. 05HumanNon-randomized trialEfficacy outcome

    After knee replacement, hematocrit was significantly lower with desmopressin than tranexamic acid from the sixth hour until 3 days.

    In plain wordsAfter knee replacement, hematocrit was lower with desmopressin than tranexamic acid from the sixth hour until 3 days.

    Peptide
    Desmopressin
    Outcome
    DecreaseHematocrit
    Study

    n: not reported in source

    Comparator
    Tranexamic acid
    Outcome group
    Bleeding · Whole body
    Studied dose
    0.3 mg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    From the sixth postoperative hour until 3 days postoperatively, Hct levels were significantly lower in the desmopressin group than in the TA group.
    2 context sentences
    Summary · context
    A prospective, single-blind study of 40 patients undergoing TKR was performed.
    Summary · context
    In the desmopressin group, desmopressin (0.3 mg/kg) and saline were administered by a similar protocol.
  6. 06HumanNon-randomized trialEfficacy outcome

    After knee replacement, desmopressin patients received more allogeneic blood: 11 patients received 16 units versus 3 patients receiving 1 unit each with tranexamic acid (p<0.02).

    In plain wordsAfter knee replacement, patients received more allogeneic blood with desmopressin than with tranexamic acid.

    Peptide
    Desmopressin
    Outcome
    IncreaseAllogeneic blood transfusion
    Study

    n: not reported in source

    Comparator
    Tranexamic acid
    Outcome group
    Blood Transfusion · Whole body
    Studied dose
    0.3 mg/kg · intravenousAs given in this study (human).

    Measurements

    Patients transfused
    11 patients
    desmopressin
    Units transfused
    16 units
    desmopressin
    Patients transfused
    3 patients
    tranexamic acid
    Units transfused per patient
    1 unit
    tranexamic acid
    P value
    < 0.02
    desmopressin versus tranexamic acid

    Source sentences

    Summary
    Significantly more allogeneic blood was transfused in the desmopressin group (11 patients received 16 units) than in the TA group (3 patients each received 1 unit) (p<0.02).
    2 context sentences
    Summary · context
    A prospective, single-blind study of 40 patients undergoing TKR was performed.
    Summary · context
    In the desmopressin group, desmopressin (0.3 mg/kg) and saline were administered by a similar protocol.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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