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Study · Randomized controlled trial · n = 11 · 2001

4 results

Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans.

Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, van der Lely AJ, Deghenghi R, Ghigo E

The Journal of clinical endocrinology and metabolism1 Oct 2001Cited by 481 (Europe PMC)

PMID11600590 (opens in a new tab)DOI10.1210/jcem.86.10.8098 (opens in a new tab)PepBankPUB-11600590
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 11 normal young volunteers, hexarelin markedly increased growth hormone release compared with saline.

    In plain wordsIn 11 healthy young adults, hexarelin raised growth hormone release more than saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release after hexarelin
    Study

    n = 11

    Comparator
    Placebo (saline)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · acute administrationAs given in this study (human).

    Measurements

    GH DeltaAUC(0-180)
    4156.8 microg/l/h
    hexarelin

    Source sentences

    Summary
    despite its marked GH-releasing effect (DeltaAUC(0-180): 4156.8 +/- 1180.3 microg/l/h; p < 0.01 vs. saline)
    1 context sentence
    Summary · context
    To this goal, we compared the effects of ghrelin, hexarelin, a synthetic GHS, or placebo on insulin and glucose as well as on GH levels in 11 normal young volunteers (age [mean +/- SEM]: 28.5 +/- 3.1 yr; BMI: 22.2 +/- 0.9 Kg/m(2)).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In 11 normal young volunteers, hexarelin did not modify glucose levels.

    In plain wordsIn 11 healthy young adults, hexarelin did not change blood glucose.

    Peptide
    Hexarelin
    Outcome
    No significant changeGlucose levels after hexarelin
    Study

    n = 11

    Comparator
    Placebo (saline)
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · acute administrationAs given in this study (human).

    Source sentences

    Summary
    Hexarelin administration did not modify glucose and insulin levels
    1 context sentence
    Summary · context
    To this goal, we compared the effects of ghrelin, hexarelin, a synthetic GHS, or placebo on insulin and glucose as well as on GH levels in 11 normal young volunteers (age [mean +/- SEM]: 28.5 +/- 3.1 yr; BMI: 22.2 +/- 0.9 Kg/m(2)).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In 11 normal young volunteers, hexarelin did not modify insulin levels.

    In plain wordsIn 11 healthy young adults, hexarelin did not change blood insulin.

    Peptide
    Hexarelin
    Outcome
    No significant changeInsulin levels after hexarelin
    Study

    n = 11

    Comparator
    Placebo (saline)
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    Dose not stated · acute administrationAs given in this study (human).

    Source sentences

    Summary
    Hexarelin administration did not modify glucose and insulin levels
    1 context sentence
    Summary · context
    To this goal, we compared the effects of ghrelin, hexarelin, a synthetic GHS, or placebo on insulin and glucose as well as on GH levels in 11 normal young volunteers (age [mean +/- SEM]: 28.5 +/- 3.1 yr; BMI: 22.2 +/- 0.9 Kg/m(2)).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In 11 normal young volunteers, the growth hormone response to hexarelin was slightly lower than that to ghrelin.

    In plain wordsIn 11 healthy young adults, hexarelin raised growth hormone slightly less than ghrelin did.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH release after hexarelin versus ghrelin
    Study

    n = 11

    Comparator
    Ghrelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · acute administrationAs given in this study (human).

    Source sentences

    Summary
    that was slightly lower (p < 0.05) than that of ghrelin.
    1 context sentence
    Summary · context
    To this goal, we compared the effects of ghrelin, hexarelin, a synthetic GHS, or placebo on insulin and glucose as well as on GH levels in 11 normal young volunteers (age [mean +/- SEM]: 28.5 +/- 3.1 yr; BMI: 22.2 +/- 0.9 Kg/m(2)).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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