Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine.

Prkacin I, Separovic J, Aralicia G, Perovic D, Gjurasin M, Lovric-Bencic M, Stancic-Rokotov D, Staresinic M, Anic T, Mikus D, Sikiric P, Seiwerth S and 10 more

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Mise S, Rotkvic I, Jagic V, Rucman R, Petek M, Turkovic B, Marovic A, Sebecic B, Boban-Blagaic A, Kokic N

Journal of physiology, Paris1 Jan 2001Cited by 34 (Europe PMC)

PMID11595456DOI10.1016/s0928-4257(01)00044-4PepBankPUB-11595456

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats drinking alcohol chronically, BPC‑157 reduced the raised portal pressure to the values of healthy rats.
In plain wordsIn rats drinking alcohol for months, BPC‑157 brought the raised pressure in the liver's portal vein back to healthy levels.
Peptide
BPC-157
Outcome
DecreasePortal blood pressure
Study
ratn: not reported in source
chronic alcohol drinking
Comparator
Saline control
Outcome group
Blood pressure · Liver
Studied dose
10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · whole 3 months or last month onlyAs given in this study (rat).
Source sentences
Summary
In rats that received gastric pentadecapeptide BPC 157 or propranolol the otherwise raised portal pressure was reduced to the values noted in healthy rats.
2 context sentences(design, population, supporting numbers)
Summary · context
Portal hypertension (mm Hg) assessed directly into the portal vein, and liver lesions induced by 7.28 g/kg b.w. of alcohol given in drinking water for 3 months
Summary · context
The medication (once daily) was throughout either the whole 3 months period (1) or the last month only (2) (last application 24 h before sacrifice).
Report a problemFND-1159545601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats drinking alcohol chronically, BPC‑157 showed both prophylactic and therapeutic effects against portal hypertension.
In plain wordsIn rats drinking alcohol for months, BPC‑157 both prevented and reversed high portal vein pressure.
Peptide
BPC-157
Outcome
DecreasePrevention and reversal of portal hypertension
Study
ratn: not reported in source
chronic alcohol drinking
Comparator
Saline control
Outcome group
Blood pressure · Liver
Studied dose
10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · whole 3 months or last month onlyAs given in this study (rat).
Source sentences
Summary
Both prophylactic and therapeutic effects were shown.
3 context sentences(design, population, supporting numbers)
Summary · context
pentadecapeptide BPC 157, and propranolol may prevent portal hypertension as well as reverse already established portal hypertension along with related liver disturbances.
Summary · context
Portal hypertension (mm Hg) assessed directly into the portal vein, and liver lesions induced by 7.28 g/kg b.w. of alcohol given in drinking water for 3 months
Summary · context
The medication (once daily) was throughout either the whole 3 months period (1) or the last month only (2) (last application 24 h before sacrifice).
Report a problemFND-1159545602
03AnimalAnimal study (in vivo)Efficacy outcome
In rats drinking alcohol chronically, the abstract reports that the raised hepatocyte area and circumference and the raised liver weight were completely eliminated (not different from healthy rats) in treated groups; this sentence does not name the agent, but the abstract summary names BPC‑157 and propranolol.
In plain wordsIn rats drinking alcohol for months, liver cell size and liver weight returned to healthy values in treated groups (BPC‑157 and propranolol).
Peptide
BPC-157
Outcome
DecreaseHepatocyte area and circumference, and liver weight
Study
ratn: not reported in source
chronic alcohol drinking
Comparator
Saline control
Outcome group
Liver fat and liver function · Liver
Studied dose
10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · whole 3 months or last month onlyAs given in this study (rat).
Source sentences
Summary
Some of them were completely eliminated (not different from healthy rats, i.e. portal pressure, the circumference and area of hepatocytes, liver weight)
2 context sentences(design, population, supporting numbers)
Summary · context
Portal hypertension (mm Hg) assessed directly into the portal vein, and liver lesions induced by 7.28 g/kg b.w. of alcohol given in drinking water for 3 months
Summary · context
The medication (once daily) was throughout either the whole 3 months period (1) or the last month only (2) (last application 24 h before sacrifice).
Report a problemFND-1159545603
04AnimalAnimal study (in vivo)Efficacy outcome
In rats drinking alcohol chronically, the raised hepatocyte nucleus area and circumference were markedly attenuated in treated groups, though still higher than in healthy rats; this sentence does not name the agent, but the abstract summary names BPC‑157 and propranolol.
In plain wordsIn rats drinking alcohol for months, liver cell nuclei got smaller but stayed larger than normal in treated groups (BPC‑157 and propranolol).
Peptide
BPC-157
Outcome
DecreaseHepatocyte nucleus area and circumference
Study
ratn: not reported in source
chronic alcohol drinking
Comparator
Saline control
Outcome group
Liver fat and liver function · Liver
Studied dose
10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · whole 3 months or last month onlyAs given in this study (rat).
Source sentences
Summary
while others were markedly attenuated (values less than in drinking controls, still higher than in healthy rats, i.e. circumference and area of hepatocytes nucleus).
2 context sentences(design, population, supporting numbers)
Summary · context
Portal hypertension (mm Hg) assessed directly into the portal vein, and liver lesions induced by 7.28 g/kg b.w. of alcohol given in drinking water for 3 months
Summary · context
The medication (once daily) was throughout either the whole 3 months period (1) or the last month only (2) (last application 24 h before sacrifice).
Report a problemFND-1159545604

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

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Publication types

Journal Article

MeSH terms

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