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Study · Animal study (in vivo) · rat · 2001

4 results

Lung lesions and anti-ulcer agents beneficial effect: anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lung lesion in rats.

Stancic-Rokotov D, Slobodnjak Z, Aralica J, Aralica G, Perovic D, Staresinic M, Gjurasin M, Anic T, Zoricic I, Buljat G, Prkacin I, Sikiric P and 7 more

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Seiwerth S, Rucman R, Petek M, Turkovic B, Kokic N, Jagic V, Boban-Blagaic A

Journal of physiology, Paris1 Jan 2001Cited by 17 (Europe PMC)

PMID11595454 (opens in a new tab)DOI10.1016/s0928-4257(01)00042-0 (opens in a new tab)PepBankPUB-11595454
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with HCl-induced lung lesions, a single co-treatment attenuated lung lesions relative to controls for the agents other than omeprazole, which includes BPC‑157.

    In plain wordsIn rats with acid-induced lung injury, BPC‑157 given at the time of injury reduced lung lesions compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseLung lesions, co-treatment
    Study

    ratn: not reported in source

    HCl-induced lung lesion
    Comparator
    Controls
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µg, 10 ng or 10 pg/kg · intraperitoneal · single co-treatment at time 0As given in this study (rat).

    Source sentences

    Summary
    In single application studies, relative to controls, a co-treatment (except to omeprazole), a pre-treatment (at -1 h) (pentadecapeptide BPC 157 and atropine, but not ranitidine and omeprazole) regularly attenuated
    2 context sentences
    Summary · context
    Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), then sacrificed 1 h after ethanol.
    Summary · context
    Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with HCl-induced lung lesions, a single BPC‑157 pre-treatment regularly attenuated lung lesions relative to controls.

    In plain wordsIn rats with acid-induced lung injury, BPC‑157 given before the injury reduced lung lesions compared with controls.

    Peptide
    BPC-157
    Outcome
    DecreaseLung lesions, pre-treatment
    Study

    ratn: not reported in source

    HCl-induced lung lesion
    Comparator
    Controls
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µg, 10 ng or 10 pg/kg · intraperitoneal · single pre-treatment, 1 h before injuryAs given in this study (rat).

    Source sentences

    Summary
    In single application studies, relative to controls, a co-treatment (except to omeprazole), a pre-treatment (at -1 h) (pentadecapeptide BPC 157 and atropine, but not ranitidine and omeprazole) regularly attenuated
    2 context sentences
    Summary · context
    Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), then sacrificed 1 h after ethanol.
    Summary · context
    Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with HCl-induced lung lesions, the highest BPC‑157 dose given therapeutically reversed the otherwise more severe lung lesions.

    In plain wordsIn rats with acid-induced lung injury, the highest BPC‑157 dose given after the injury reversed the more severe lung lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseLung lesions, therapeutic treatment
    Study

    ratn: not reported in source

    HCl-induced lung lesion
    Comparator
    Controls
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    highest dose · intraperitoneal · single therapeutic treatmentAs given in this study (rat).

    Source sentences

    Summary
    while therapeutically, atropine (at +18 h), pentadecapeptide BPC 157 highest dose and omeprazole (at +24 h), reversed the otherwise more severe lung lesions.
    2 context sentences
    Summary · context
    Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), then sacrificed 1 h after ethanol.
    Summary · context
    Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)

Studies that did not test the peptide alone1

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 04AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In rats with HCl-induced lung lesions, combined prophylactic and therapeutic regimens of all tested antiulcer agents (BPC‑157, ranitidine, atropine, omeprazole) attenuated lung lesions.

    In plain wordsIn rats with acid-induced lung injury, repeated treatment with each of four anti-ulcer drugs, including BPC‑157, reduced lung lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseLung lesions, combined prophylactic and therapeutic regimens (all agents)
    Study

    ratn: not reported in source

    HCl-induced lung lesion
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    For all agents, combining their prophylactic and salutary regimens (at -1 h/+24 h, or at 0/+24 h) attenuated lung lesions
    2 context sentences
    Summary · context
    Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), then sacrificed 1 h after ethanol.
    Summary · context
    Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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