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Study · Animal study (in vivo) · rat · 2001

3 results

Chronic cytoprotection: pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats.

Prkacin I, Aralica G, Perovic D, Separovic J, Gjurasin M, Lovric-Bencic M, Stancic-Rokotov D, Ziger T, Anic T, Sikiric P, Seiwerth S, Staresinic M and 11 more

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Mise S, Rotkvic I, Jagic V, Rucman R, Petek M, Turkovic B, Marovic A, Sjekavica I, Sebecic B, Boban-Blagaic A, Ivasovic Z

Journal of physiology, Paris1 Jan 2001Cited by 20 (Europe PMC)

PMID11595453 (opens in a new tab)DOI10.1016/s0928-4257(01)00041-9 (opens in a new tab)PepBankPUB-11595453
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats that later drank alcohol chronically, BPC‑157 given before alcohol drinking may prevent gastric lesion development.

    In plain wordsIn rats given alcohol for months, BPC‑157 given before alcohol may prevent stomach lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseGastric lesions, prophylactic regimen
    Study

    ratn: not reported in source

    chronic alcohol drinking
    Comparator
    Saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · 10 days before alcohol drinkingAs given in this study (rat).

    Source sentences

    Summary
    Pentadecapeptide BPC 157, ranitidine and propranolol may prevent gastric lesion development if given prophylactically, before alcohol drinking.
    2 context sentences
    Summary · context
    Therefore, focus was on the antiulcer effect of the gastric pentadecapeptide BPC 157, GEPPPGKPADDAGLV, M.W. 1419, known to have a beneficial effect in variety of gastrointestinal lesions models (10 microg or 10 ng/kg b.w. i.p. or i.g.), ranitidine (10 mg/kg b.w. i.g.) and propranol (10 mg/kg b.w. i.…
    Summary · context
    They were given once daily (1) throughout 10 days preceding alcohol consumption, (2) since beginning of alcohol drinking till the end of the study, (3) throughout the last month of alcohol consumption, 2 months after alcohol drinking had been initiated.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats drinking alcohol chronically, BPC‑157 given once daily throughout the drinking period attenuated gastric lesion appearance.

    In plain wordsIn rats drinking alcohol for months, daily BPC‑157 reduced stomach lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseGastric lesions, regimen throughout drinking
    Study

    ratn: not reported in source

    chronic alcohol drinking
    Comparator
    Saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · from the start of alcohol drinking to the end of the studyAs given in this study (rat).

    Source sentences

    Summary
    Likewise, they attenuate the lesion appearance given once daily throughout the drinking period.
    2 context sentences
    Summary · context
    Therefore, focus was on the antiulcer effect of the gastric pentadecapeptide BPC 157, GEPPPGKPADDAGLV, M.W. 1419, known to have a beneficial effect in variety of gastrointestinal lesions models (10 microg or 10 ng/kg b.w. i.p. or i.g.), ranitidine (10 mg/kg b.w. i.g.) and propranol (10 mg/kg b.w. i.…
    Summary · context
    They were given once daily (1) throughout 10 days preceding alcohol consumption, (2) since beginning of alcohol drinking till the end of the study, (3) throughout the last month of alcohol consumption, 2 months after alcohol drinking had been initiated.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats drinking alcohol chronically, BPC‑157 given therapeutically may antagonize gastric mucosal lesions that were already present.

    In plain wordsIn rats drinking alcohol for months, BPC‑157 given after lesions had appeared may reduce stomach lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseGastric lesions, therapeutic regimen
    Study

    ratn: not reported in source

    chronic alcohol drinking
    Comparator
    Saline control
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal or intragastric · last month of alcohol consumptionAs given in this study (rat).

    Source sentences

    Summary
    Importantly, when given therapeutically, they may antagonize otherwise pertinent lesion presence in stomach mucosa of the drinking rats.
    2 context sentences
    Summary · context
    Therefore, focus was on the antiulcer effect of the gastric pentadecapeptide BPC 157, GEPPPGKPADDAGLV, M.W. 1419, known to have a beneficial effect in variety of gastrointestinal lesions models (10 microg or 10 ng/kg b.w. i.p. or i.g.), ranitidine (10 mg/kg b.w. i.g.) and propranol (10 mg/kg b.w. i.…
    Summary · context
    They were given once daily (1) throughout 10 days preceding alcohol consumption, (2) since beginning of alcohol drinking till the end of the study, (3) throughout the last month of alcohol consumption, 2 months after alcohol drinking had been initiated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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