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Study · Not a test of the peptide alone · 2001

2 results

Ethanol gastric lesion aggravated by lung injury in rat. Therapy effect of antiulcer agents.

Stancic-Rokotov D, Sikiric P, Seiwerth S, Slobodnjak Z, Aralica J, Aralica G, Perovic D, Anic T, Zoricic I, Buljat G, Prkacin I, Gjurasin M and 7 more

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Rucman R, Petek M, Turkovic B, Ivasovic Z, Jagic V, Staresinic M, Boban-Blagaic A

Journal of physiology, Paris1 Jan 2001Cited by 12 (Europe PMC)

PMID11595452 (opens in a new tab)DOI10.1016/s0928-4257(01)00040-7 (opens in a new tab)PepBankPUB-11595452
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 01AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In rats with HCl lung injury, the antiulcer agents tested (BPC‑157, ranitidine, atropine, omeprazole) protected against ethanol gastric lesions in all regimens.

    In plain wordsIn rats with lung injury, four anti-ulcer drugs, including BPC‑157, protected the stomach against ethanol damage.

    Peptide
    BPC-157
    Outcome
    DecreaseEthanol gastric lesions with lung injury (antiulcer agents pooled)
    Study

    ratn: not reported in source

    ethanol gastric lesion after HCl lung injury
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    In general, the antiulcer agents did protect against ethanol gastric lesions regardless of the presence of the severe lung injury, in all of the used regimens.
    2 context sentences
    Summary · context
    Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung-lesion), and an intragastric instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), and were sacrificed 1 h after ethanol.
    Summary · context
    Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (PL-10, PLD-116; 10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  2. 02AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In rats with HCl lung injury, combining prophylactic and salutary regimens of the antiulcer agents tested may increase the antiulcer potential, and effects absent with a single application became prominent after repeated treatment.

    In plain wordsIn rats with lung injury, repeating anti-ulcer drug treatment, including BPC‑157, may increase stomach protection.

    Peptide
    BPC-157
    Outcome
    IncreaseAntiulcer potential of repeated prophylactic and therapeutic treatment (antiulcer agents pooled)
    Study

    ratn: not reported in source

    ethanol gastric lesion after HCl lung injury
    Outcome group
    Gastrointestinal protection · Gastrointestinal

    Source sentences

    Summary
    Of note, combining their prophylactic and salutary regimens (at -1 h/+24 h, or at 0/+24 h) may increase the antiulcer potential, and the effect that had been not seen already with single application, became prominent after repeated treatment.
    2 context sentences
    Summary · context
    Rats received an intratracheal (i.t.) HCl instillation [1.5 ml/kg HCl (pH 1.75)] (lung-lesion), and an intragastric instillation of 96% ethanol (gastric lesion; 1 ml/rat, 24 h after i.t. HCl instillation), and were sacrificed 1 h after ethanol.
    Summary · context
    Taking intratracheal HCl-instillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (PL-10, PLD-116; 10 microg, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg), omeprazole (10 mg)

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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Publication types

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