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Study · Animal study (in vivo) · rat · 2001

5 results

Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats.

Kovacs M, Schally AV

Proceedings of the National Academy of Sciences of the United States of America1 Oct 2001Cited by 25 (Europe PMC)

PMID11593037 (opens in a new tab)PMCIDPMC59791 (opens in a new tab)DOI10.1073/pnas.211442598 (opens in a new tab)PepBankPUB-11593037
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, daily triptorelin injections suppressed pituitary LHRH receptor mRNA by 41%.

    In plain wordsIn rats with removed ovaries, daily triptorelin injections reduced pituitary receptor gene expression by 41%.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePituitary LHRH receptor mRNA in OVX rats
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg daily · injectionAs given in this study (rat).

    Measurements

    LHRH receptor mRNA suppression
    41%
    triptorelin in OVX rats

    Source sentences

    Summary
    In OVX rats, 10 days after administration of a depot formulation of cetrorelix, releasing 100 microg of peptide daily, the elevated LHRH-R mRNA level was decreased by 73%, whereas daily injection of 100 microg of triptorelin caused a 41% suppression.
    1 context sentence
    Summary · context
    We also compared the effects of chronic administration of cetrorelix and triptorelin on the LHRH-R mRNA level and gonadotropin secretion in ovariectomized (OVX) and normal female rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In normal female rats, triptorelin increased pituitary LHRH receptor mRNA by 150%.

    In plain wordsIn normal female rats, triptorelin increased pituitary receptor gene expression by 150%.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePituitary LHRH receptor mRNA in normal rats
    Study

    ratn: not reported in source

    Normal female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    LHRH receptor mRNA increase
    150%
    triptorelin in normal female rats

    Source sentences

    Summary
    In normal female rats, cetrorelix treatment suppressed the LHRH-R mRNA level by 33%, but triptorelin increased it by 150%.
    1 context sentence
    Summary · context
    We also compared the effects of chronic administration of cetrorelix and triptorelin on the LHRH-R mRNA level and gonadotropin secretion in ovariectomized (OVX) and normal female rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, triptorelin decreased serum LH to the precastration level.

    In plain wordsIn rats with removed ovaries, triptorelin reduced blood LH to the level before castration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseSerum LH in OVX rats
    Study

    ratn: not reported in source

    Ovariectomized rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Triptorelin decreased the serum LH in OVX rats to the precastration level, but had no effect on basal LH in normal rats.
    1 context sentence
    Summary · context
    We also compared the effects of chronic administration of cetrorelix and triptorelin on the LHRH-R mRNA level and gonadotropin secretion in ovariectomized (OVX) and normal female rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In normal rats, triptorelin did not affect basal serum LH.

    In plain wordsIn normal rats, triptorelin did not change basal blood LH.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeBasal serum LH in normal rats
    Study

    ratn: not reported in source

    Normal rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Triptorelin decreased the serum LH in OVX rats to the precastration level, but had no effect on basal LH in normal rats.
    1 context sentence
    Summary · context
    We also compared the effects of chronic administration of cetrorelix and triptorelin on the LHRH-R mRNA level and gonadotropin secretion in ovariectomized (OVX) and normal female rats.
  5. 05LabIn vitro (cells)Mechanism

    In pituitary cells, pulsatile triptorelin increased LHRH receptor mRNA expression.

    In plain wordsIn cells, pulsatile triptorelin increased receptor gene expression.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseLHRH receptor mRNA expression in vitro
    Study

    n: not reported in source

    Pituitary cells
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.1 nM · 5 hAs given in this study.

    Source sentences

    Summary
    The exposure of pituitary cells in vitro to 3-min pulses of 1 nM LHRH or 0.1 nM triptorelin for 5 h increased the LHRH-R mRNA level by 77-88%.
    1 context sentence
    Summary · context
    We also compared the effects of chronic administration of cetrorelix and triptorelin on the LHRH-R mRNA level and gonadotropin secretion in ovariectomized (OVX) and normal female rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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