Skip to content

Study · Ex vivo tissue · 2001

7 results

Hexarelin--evaluation of factors influencing oral bioavailability and ways to improve absorption.

Westberg C, Benkestock K, Fatouros A, Svensson M, Sjöström B

The Journal of pharmacy and pharmacology1 Sept 2001Cited by 6 (Europe PMC)

PMID11578108 (opens in a new tab)DOI10.1211/0022357011776540 (opens in a new tab)PepBankPUB-11578108
Source linkPubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    Hexarelin permeability across rat ileum and in Caco-2 cell monolayers was low.

    In plain wordsIn lab tests with rat gut tissue and gut cells, little hexarelin crossed the barrier.

    Peptide
    Hexarelin
    Outcome
    Not applicableHexarelin permeability across rat ileum and Caco-2 monolayers
    Study

    n: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hexarelin permeability across rat ileum and in Caco-2 cell monolayers was low.

Studies that did not test the peptide alone6

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 02LabNot a test of Hexarelin aloneEx vivo tissueOther

    Hexarelin was degraded in the presence of intestinal contents.

    In plain wordsIn lab tests, hexarelin broke down when mixed with gut contents.

    Peptide
    Hexarelin
    Outcome
    Not applicableDegradation of hexarelin by intestinal contents
    Study

    n: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    It was found that hexarelin was degraded in the presence of the contents of the intestine.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 03LabNot a test of Hexarelin aloneEx vivo tissueOther

    The metabolite was identified as hexarelin deamidated at the lysine residue.

    In plain wordsIn lab tests, hexarelin broke down into a product with a chemical change at its lysine.

    Peptide
    Hexarelin
    Outcome
    Not applicableIdentity of the hexarelin metabolite
    Study

    n: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The metabolite was identified as hexarelin deamidated at the lysine residue.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 04LabNot a test of Hexarelin aloneEx vivo tissueOther

    Chymostatin, Pefabloc SC, EDTA and EGTA inhibited the degradation of hexarelin in the contents of rat ileum.

    In plain wordsIn lab tests with rat gut contents, four additives slowed the breakdown of hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseInhibition of hexarelin degradation in rat ileum contents
    Study

    ratn: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The degradation of hexarelin in the contents of rat ileum was inhibited by the addition of chymostatin, Pefabloc SC, EDTA, and EGTA.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  4. 05LabNot a test of Hexarelin aloneEx vivo tissueOther

    Hexarelin permeability increased in the presence of different permeability enhancing agents.

    In plain wordsIn lab tests, several added agents raised the amount of hexarelin that crossed the gut barrier.

    Peptide
    Hexarelin
    Outcome
    IncreaseEffect of permeability enhancing agents on hexarelin permeability
    Study

    n: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    An increase in hexarelin permeability was observed in the presence of different permeability enhancing agents.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  5. 06LabNot a test of Hexarelin aloneIn vitro (cell-free)Other

    Pancreatic proteases from pancreas substitute drugs degraded hexarelin, and Pefabloc SC inhibited this degradation.

    In plain wordsIn lab tests, digestive enzymes from pancreas drugs broke down hexarelin, and an added inhibitor stopped this.

    Peptide
    Hexarelin
    Outcome
    Not applicableDegradation of hexarelin by pancreatic proteases
    Study

    n: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Furthermore, the presence of pancreatic proteases from pancrease substitute drugs caused a degradation of hexarelin that could be inhibited by the addition of Pefabloc SC.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  6. 07LabNot a test of Hexarelin aloneIn vitro (cell-free)Other

    The same hexarelin metabolite as in rat ileum contents was found with human, porcine and bovine trypsin.

    In plain wordsIn lab tests, trypsin from three species produced the same hexarelin breakdown product as rat gut contents.

    Peptide
    Hexarelin
    Outcome
    Not applicableHexarelin metabolite with human, porcine and bovine trypsin
    Study

    n: not reported in source

    rat intestinal contents, rat ileum and Caco-2 monolayers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The same hexarelin metabolite that was found with the contents of rat ileum was found in the presence of human, porcine and bovine trypsin.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.