OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats.

Kostenuik PJ, Capparelli C, Morony S, Adamu S, Shimamoto G, Shen V, Lacey DL, Dunstan CR

Endocrinology1 Oct 2001Cited by 97 (Europe PMC)

PMID11564687DOI10.1210/endo.142.10.8437PepBankPUB-11564687

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH alone increased lumbar vertebral bone mineral density versus vehicle.
In plain wordsIn rats, PTH alone increased lumbar vertebral bone density compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLumbar vertebral bone mineral density
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg three times per week · subcutaneous · 5.5 monthsAs given in this study (rat).
Source sentences
Summary
Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
Report a problemFND-1156468701
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH alone increased femoral bone mineral density versus vehicle.
In plain wordsIn rats, PTH alone increased femoral bone density compared with vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral bone mineral density
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg three times per week · subcutaneous · 5.5 monthsAs given in this study (rat).
Source sentences
Summary
Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
Report a problemFND-1156468702
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, adding PTH to OPG produced greater and faster lumbar bone density increases than OPG alone.
In plain wordsIn rats, adding PTH to OPG increased lumbar bone density more and faster than OPG alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLumbar vertebral bone mineral density with OPG
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
OPG alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg three times per week · subcutaneous · 5.5 monthsAs given in this study (rat).
Source sentences
Summary
Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
Report a problemFND-1156468703
04AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, adding PTH to OPG produced greater and faster femoral bone density increases than OPG alone.
In plain wordsIn rats, adding PTH to OPG increased femoral bone density more and faster than OPG alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral bone mineral density with OPG
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
OPG alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
80 microg/kg three times per week · subcutaneous · 5.5 monthsAs given in this study (rat).
Source sentences
Summary
Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
Report a problemFND-1156468704

Studies that did not test the peptide alone4

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, OPG plus PTH increased lumbar bone density more and faster than PTH alone.
In plain wordsIn rats, OPG plus PTH increased lumbar bone density more and faster than PTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLumbar vertebral bone mineral density combination
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
PTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1156468705
06AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, OPG plus PTH increased femoral bone density more and faster than PTH alone.
In plain wordsIn rats, OPG plus PTH increased femoral bone density more and faster than PTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseFemoral bone mineral density combination
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
PTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Treatment of ovariectomized rats with OPG or PTH alone increased bone mineral density in the lumbar vertebrae and femur, whereas PTH plus OPG caused significantly greater and more rapid increases than either therapy alone (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1156468706
07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, OPG plus PTH reversed lumbar vertebral stiffness deficits more effectively than PTH alone.
In plain wordsIn rats, OPG plus PTH restored lumbar vertebral stiffness more than PTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLumbar vertebral stiffness
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
PTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the lumbar vertebrae, OPG plus PTH was significantly more effective than PTH alone at reversing ovariectomy-induced deficits in stiffness and elastic modulus.
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1156468707
08AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, OPG plus PTH reversed lumbar elastic modulus deficits more effectively than PTH alone.
In plain wordsIn rats, OPG plus PTH restored lumbar elastic modulus more than PTH alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseLumbar vertebral elastic modulus
Study
ratn: not reported in source
Severely osteopenic ovariectomized Sprague Dawley rats
Comparator
PTH alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
In the lumbar vertebrae, OPG plus PTH was significantly more effective than PTH alone at reversing ovariectomy-induced deficits in stiffness and elastic modulus.
2 context sentences(design, population, supporting numbers)
Summary · context
Sprague Dawley rats were sham-operated or ovariectomized at 3 months of age.
Summary · context
Rats were then treated for 5.5 months with vehicle (PBS), human PTH-(1-34) (80 microg/kg), rat OPG (10 mg/kg), or OPG plus PTH (all three times per wk, sc).
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1156468708

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 2 completed · 2 with posted results · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4Results postedNCT01750086

Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption

Massachusetts General Hospitaln = 27Jan 2013 to Aug 2014

Postmenopausal Osteoporosis

Trial page ClinicalTrials.govUpdated 27 Mar 2017

CompletedPhase 2Results postedNCT00926380

Denosumab, Teriparatide or Both for the Treatment of Postmenopausal Osteoporosis

Massachusetts General Hospitaln = 94Jun 2009 to Dec 2016

Osteoporosis

Trial page ClinicalTrials.govUpdated 29 Jun 2018

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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