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Study · Animal study (in vivo) · rat · 2001

4 results

[Gene c-Fos expression in brain of rats resistant and predisposed to emotional stress after intraperitoneal injection of the ACTH(4-10)analog--semax].

Umriukhin PE, Koplik EV, Grivennikov IA, Miasoedov NF, Sudakov KV

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Mar 2001Cited by 4 (Europe PMC)

PMID11548604 (opens in a new tab)PepBankPUB-11548604
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats predisposed to emotional stress under usual conditions, intraperitoneal semax induced c-Fos expression in the lateral septal region.

    In plain wordsIn stress-prone rats, semax injection switched on the c-Fos gene in a brain region called the lateral septum.

    Peptide
    Semax
    Outcome
    Increasec-Fos expression in lateral septal region without stress
    Study

    ratsn: not reported in source

    Wistar rats with high or low resistance to emotional stress
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rats).

    Source sentences

    Summary
    under the usual conditions the intraperitoneal Semax injection induced immediate early gene c-Fos expression in the lateral septal region in rats predisposed to emotional stress and in the paraventricular hypothalamus in rats of both groups.
    1 context sentence
    Summary · context
    The effect of the ACTH(4-10) analog Semax on immediate early gene c-Fos expression was studied in Wistar rats with high and low resistance to emotional stress under the usual conditions and during psychoemotional loading.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats resistant to and rats predisposed to emotional stress, intraperitoneal semax induced c-Fos expression in the paraventricular hypothalamus under usual conditions.

    In plain wordsIn both stress-resistant and stress-prone rats, semax injection switched on the c-Fos gene in the hypothalamus.

    Peptide
    Semax
    Outcome
    Increasec-Fos expression in paraventricular hypothalamus without stress
    Study

    ratsn: not reported in source

    Wistar rats with high or low resistance to emotional stress
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rats).

    Source sentences

    Summary
    under the usual conditions the intraperitoneal Semax injection induced immediate early gene c-Fos expression in the lateral septal region in rats predisposed to emotional stress and in the paraventricular hypothalamus in rats of both groups
    1 context sentence
    Summary · context
    The effect of the ACTH(4-10) analog Semax on immediate early gene c-Fos expression was studied in Wistar rats with high and low resistance to emotional stress under the usual conditions and during psychoemotional loading.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats predisposed to emotional stress, preliminary semax injection decreased stress-induced c-Fos expression in the paraventricular hypothalamus and medial septum.

    In plain wordsIn stress-prone rats, semax given before stress lowered stress-triggered c-Fos gene activity in two brain regions.

    Peptide
    Semax
    Outcome
    DecreaseStress-induced c-Fos in paraventricular hypothalamus and medial septum
    Study

    ratsn: not reported in source

    Wistar rats with high or low resistance to emotional stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rats).

    Source sentences

    Summary
    Preliminary Semax injection decreased the stress-induced c-Fos expression in the paraventricular hypothalamus and medial septum in rats predisposed to emotional stress
    1 context sentence
    Summary · context
    The effect of the ACTH(4-10) analog Semax on immediate early gene c-Fos expression was studied in Wistar rats with high and low resistance to emotional stress under the usual conditions and during psychoemotional loading.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In both rat groups, semax tended to reduce the number of stress-induced c-Fos-positive cells in the lateral septum and basolateral amygdala, with no clear significant effect reported.

    In plain wordsIn rats, semax before stress only tended to lower stress-triggered c-Fos activity in two brain regions. No clear effect was reported.

    Peptide
    Semax
    Outcome
    No significant changeStress-induced c-Fos in lateral septum and basolateral amygdala
    Study

    ratsn: not reported in source

    Wistar rats with high or low resistance to emotional stress
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rats).

    Source sentences

    Summary
    and tended to reduce the number of stress-induced c-Fos-immunopositive cells in the lateral septum and basolateral amygdala in both groups of animals.
    1 context sentence
    Summary · context
    The effect of the ACTH(4-10) analog Semax on immediate early gene c-Fos expression was studied in Wistar rats with high and low resistance to emotional stress under the usual conditions and during psychoemotional loading.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    12 Oct 2026, 17:28 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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