Hormonal regulation of peripheral benzodiazepine receptor binding properties is mediated by subunit interaction.

Golani I, Weizman A, Leschiner S, Spanier I, Eckstein N, Limor R, Yanai J, Maaser K, Scherübl H, Weisinger G, Gavish M

Biochemistry1 Aug 2001Cited by 33 (Europe PMC)

PMID11513599DOI10.1021/bi010431+PepBankPUB-11513599

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In female rats, triptorelin reduced ovarian PBR binding capacity by 40%.
In plain wordsIn rats, triptorelin reduced ovarian receptor binding capacity by 40%.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOvarian PBR binding capacity
Study
ratn: not reported in source
Adult female rats with pharmacological castration
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Measurements
PBR binding capacity reduction
40%
ovaries
Source sentences
Summary
We found that PBR binding capacity dropped by 40 and 48% in ovaries and adrenals, respectively, following decapeptyl administration, as opposed to no change in the kidney.
2 context sentences(design, population, supporting numbers)
Summary · context
To accomplish this, adult female rats were pharmacologically castrated using chronic administration of the gonadotropin-releasing hormone agonist decapeptyl (triptorelin-D-Trp(6)-LHRH).
Summary · context
Half of these rats received 17beta-estradiol as hormone replacement, while a control group received daily injections of vehicle only.
Report a problemFND-1151359901
02AnimalAnimal study (in vivo)Mechanism
In female rats, triptorelin reduced adrenal PBR binding capacity by 48%.
In plain wordsIn rats, triptorelin reduced adrenal receptor binding capacity by 48%.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseAdrenal PBR binding capacity
Study
ratn: not reported in source
Adult female rats with pharmacological castration
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Measurements
PBR binding capacity reduction
48%
adrenals
Source sentences
Summary
We found that PBR binding capacity dropped by 40 and 48% in ovaries and adrenals, respectively, following decapeptyl administration, as opposed to no change in the kidney.
2 context sentences(design, population, supporting numbers)
Summary · context
To accomplish this, adult female rats were pharmacologically castrated using chronic administration of the gonadotropin-releasing hormone agonist decapeptyl (triptorelin-D-Trp(6)-LHRH).
Summary · context
Half of these rats received 17beta-estradiol as hormone replacement, while a control group received daily injections of vehicle only.
Report a problemFND-1151359902
03AnimalAnimal study (in vivo)Mechanism
In female rats, triptorelin did not change kidney PBR binding capacity.
In plain wordsIn rats, triptorelin did not change kidney receptor binding capacity.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeKidney PBR binding capacity
Study
ratn: not reported in source
Adult female rats with pharmacological castration
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
We found that PBR binding capacity dropped by 40 and 48% in ovaries and adrenals, respectively, following decapeptyl administration, as opposed to no change in the kidney.
2 context sentences(design, population, supporting numbers)
Summary · context
To accomplish this, adult female rats were pharmacologically castrated using chronic administration of the gonadotropin-releasing hormone agonist decapeptyl (triptorelin-D-Trp(6)-LHRH).
Summary · context
Half of these rats received 17beta-estradiol as hormone replacement, while a control group received daily injections of vehicle only.
Report a problemFND-1151359903
04AnimalAnimal study (in vivo)Mechanism
In female rats, the study found no evidence for transcriptional, posttranscriptional or translational mechanisms underlying triptorelin-induced PBR down-regulation.
In plain wordsIn rats, the study found no evidence that transcription or translation explained triptorelin-related receptor reductions.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableTranscriptional, posttranscriptional and translational regulation
Study
ratn: not reported in source
Adult female rats with pharmacological castration
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
We did not find evidence for transcriptional, posttranscriptional, and translational mechanisms in this decapeptyl-induced down-regulation.
2 context sentences(design, population, supporting numbers)
Summary · context
To accomplish this, adult female rats were pharmacologically castrated using chronic administration of the gonadotropin-releasing hormone agonist decapeptyl (triptorelin-D-Trp(6)-LHRH).
Summary · context
Half of these rats received 17beta-estradiol as hormone replacement, while a control group received daily injections of vehicle only.
Report a problemFND-1151359905
05AnimalAnimal study (in vivo)Mechanism
In female rats, triptorelin-associated PBR down-regulation coincided with changes in PBR subunit interactions.
In plain wordsIn rats, triptorelin-related receptor reductions coincided with changes in interactions between receptor subunits.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedPBR subunit interactions
Study
ratn: not reported in source
Adult female rats with pharmacological castration
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
In contrast, immunoprecipitation of the PBR complex, using antibodies against the 18- and 32-kDa subunits of the complex, demonstrated that there were changes in PBR subunit interactions, consistent with the down-regulation of PBR binding capacity.
2 context sentences(design, population, supporting numbers)
Summary · context
To accomplish this, adult female rats were pharmacologically castrated using chronic administration of the gonadotropin-releasing hormone agonist decapeptyl (triptorelin-D-Trp(6)-LHRH).
Summary · context
Half of these rats received 17beta-estradiol as hormone replacement, while a control group received daily injections of vehicle only.
Report a problemFND-1151359906

Studies that did not test the peptide alone1

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-castrated female rats, estradiol replacement prevented the reduction in PBR density.
In plain wordsIn rats given triptorelin, estradiol replacement prevented the reduction in receptor density.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeEstradiol prevention of PBR down-regulation
Study
ratn: not reported in source
Adult female rats with pharmacological castration
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
This down-regulation of PBR densities was prevented by estradiol replacement.
2 context sentences(design, population, supporting numbers)
Summary · context
To accomplish this, adult female rats were pharmacologically castrated using chronic administration of the gonadotropin-releasing hormone agonist decapeptyl (triptorelin-D-Trp(6)-LHRH).
Summary · context
Half of these rats received 17beta-estradiol as hormone replacement, while a control group received daily injections of vehicle only.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1151359904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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