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Study · In vitro (cells) · mouse · 2001

3 results

Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts.

Sviderskaya EV, Hill SP, Balachandar D, Barsh GS, Bennett DC

Developmental dynamics : an official publication of the American Association of Anatomists1 Aug 2001Cited by 45 (Europe PMC)

PMID11500974 (opens in a new tab)DOI10.1002/dvdy.1153 (opens in a new tab)PepBankPUB-11500974
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In murine melb-a melanoblasts, the stable alphaMSH analog NDP-MSH stimulated differentiation.

    In plain wordsIn lab tests on mouse pigment-cell precursors, NDP-MSH pushed the cells to differentiate.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMelanoblast differentiation
    Study

    mousen: not reported in source

    melb-a murine melanoblast line
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A stable analog of alphaMSH (NDP-MSH) stimulated differentiation and inhibited growth.
    1 context sentence
    Summary · context
    Here we describe conditions for both growth and induced differentiation of the melanoblast line melb-a, without feeder cells, and analyze factors that directly control proliferation and differentiation of these pure melanoblasts.
  2. 02LabIn vitro (cells)Activity measurement

    In murine melb-a melanoblasts, the stable alphaMSH analog NDP-MSH inhibited growth.

    In plain wordsIn lab tests on mouse pigment-cell precursors, NDP-MSH slowed cell growth.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseMelanoblast growth
    Study

    mousen: not reported in source

    melb-a murine melanoblast line
    Outcome group
    Pigmentation · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A stable analog of alphaMSH (NDP-MSH) stimulated differentiation and inhibited growth.
    1 context sentence
    Summary · context
    Here we describe conditions for both growth and induced differentiation of the melanoblast line melb-a, without feeder cells, and analyze factors that directly control proliferation and differentiation of these pure melanoblasts.

Studies that did not test the peptide alone1

In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan I (afamelanotide).

  1. 03LabNot a test of Melanotan I (afamelanotide) aloneIn vitro (cells)Mechanism

    In murine melb-a melanoblasts, excess agouti signaling protein (ASP) inhibited both effects of NDP-MSH, so ASP could inhibit pigmentation and stimulate growth.

    In plain wordsIn lab tests on mouse pigment-cell precursors, excess ASP blocked the effects of NDP-MSH on differentiation and growth.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseASP block of NDP-MSH effects on differentiation and growth
    Study

    mousen: not reported in source

    melb-a murine melanoblast line
    Outcome group
    Pigmentation · Skin and wound

    Source sentences

    Summary
    ASP in excess inhibited both effects of NDP-MSH, that is, ASP could inhibit pigmentation and stimulate growth.
    1 context sentence
    Summary · context
    Here we describe conditions for both growth and induced differentiation of the melanoblast line melb-a, without feeder cells, and analyze factors that directly control proliferation and differentiation of these pure melanoblasts.

    In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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