Skip to content

Study · Not a test of the peptide alone · 2001

3 results

EP 91073 prevents EP 80661-induced penile erection: new evidence for the existence of specific EP peptide receptors mediating penile erection.

Melis MR, Succu S, Spano MS, Deghenghi R, Argiolas A

Neuropharmacology1 Aug 2001Cited by 9 (Europe PMC)

PMID11489462 (opens in a new tab)DOI10.1016/s0028-3908(01)00059-4 (opens in a new tab)PepBankPUB-11489462
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Efficacy outcome

    In male rats, the hexarelin analogue EP 91073 reduced penile erection induced by EP 80661 or EP 60761 given into the paraventricular nucleus.

    In plain wordsIn male rats, a hexarelin analogue called EP 91073 reduced erections caused by two other EP peptides.

    Peptide
    Hexarelin
    Outcome
    DecreasePenile erection induced by EP 80661 or EP 60761 after EP 91073
    Study

    ratn: not reported in source

    intra-paraventricular injection in male rats
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Of the above peptides only EP 91073 (0.2-1 microg) was found capable of reducing penile erection induced by EP 80661 or EP 60761, when given into the paraventricular nucleus.
    1 context sentence
    Summary · context
    The effect of EP 91073, EP 51389, EP 70555 and EP 51216, peptide analogues of the growth hormone releasing peptide hexarelin, on penile erection induced by EP 80661 or EP 60761 injected into the paraventricular nucleus of the hypothalamus, was studied in male rats.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 02AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Mechanism

    In male rats, the hexarelin analogue EP 91073 reduced the rise in paraventricular nitric oxide production that accompanies erection induced by EP 80661 and EP 60761.

    In plain wordsIn male rats, a hexarelin analogue lowered the nitric oxide rise in a brain area linked to erection.

    Peptide
    Hexarelin
    Outcome
    DecreaseNitric oxide production in the paraventricular nucleus after EP 91073
    Study

    ratn: not reported in source

    intra-paraventricular injection in male rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The EP 91073-induced prevention of penile erection occurred with a reduction in the increase in nitric oxide production that occurs in the paraventricular nucleus concomitant to penile erection induced by EP 80661 and EP 60761, as measured by intracerebral vertical microdialysis.
    1 context sentence
    Summary · context
    The effect of EP 91073, EP 51389, EP 70555 and EP 51216, peptide analogues of the growth hormone releasing peptide hexarelin, on penile erection induced by EP 80661 or EP 60761 injected into the paraventricular nucleus of the hypothalamus, was studied in male rats.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In male rats, EP 91073 did not prevent penile erection induced by oxytocin given into the paraventricular nucleus.

    In plain wordsIn male rats, the hexarelin analogue EP 91073 did not stop the erection caused by oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin-induced penile erection after EP 91073
    Study

    ratn: not reported in source

    intra-paraventricular injection in male rats
    Outcome group
    Sexual function · Reproductive and sexual health

    Source sentences

    Summary
    Despite its ability to prevent EP peptide-induced penile erection, EP 91073 (1 microg) was unable to prevent penile erection induced by the dopamine receptor agonist apomorphine (50 ng), oxytocin (30 ng) and N-methyl-D-aspartic acid (50 ng), when given into the paraventricular nucleus 10 min prior t…
    1 context sentence
    Summary · context
    The effect of EP 91073, EP 51389, EP 70555 and EP 51216, peptide analogues of the growth hormone releasing peptide hexarelin, on penile erection induced by EP 80661 or EP 60761 injected into the paraventricular nucleus of the hypothalamus, was studied in male rats.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.