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Study · Ex vivo tissue · rat · 2001

4 results

Permeability of the peptidic GH secretagogues hexarelin and EP 51389, across rat jejunum.

Roumi M, Kwong E, Deghenghi R, Locatelli V, Marleau S, Du Souich P, Béliveau R, Ong H

Peptides1 Jul 2001Cited by 9 (Europe PMC)

PMID11445244 (opens in a new tab)DOI10.1016/s0196-9781(01)00435-1 (opens in a new tab)PepBankPUB-11445244
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    Hexarelin permeability across excised rat jejunum was below 1%.

    In plain wordsIn lab tests on rat gut tissue, less than 1% of hexarelin crossed the intestinal wall.

    Peptide
    Hexarelin
    Outcome
    Not applicableIntestinal permeability of hexarelin
    Study

    ratn: not reported in source

    excised jejunal segments in diffusion chambers
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    permeability
    < 1%
    hexarelin, rat jejunum

    Source sentences

    Summary
    Hexarelin and EP 51389 permeability were found to be < 1%.
    1 context sentence
    Summary · context
    The intestinal permeability of hexarelin and EP 51389, two growth hormone releasing hexa- and tri- peptide analogues, was assessed in vitro with side-by-side diffusion chambers in the apical-to-basolateral (AP-to-BL) and in the basolateral-to-apical (BL-to-AP) direction using excised rat jejunal segments.
  2. 02LabEx vivo tissuePharmacokinetics

    The apparent permeability coefficient of hexarelin across rat jejunum was 18.87 (x10(-7) cm/s).

    In plain wordsIn lab tests on rat gut tissue, hexarelin crossed the intestinal wall slowly.

    Peptide
    Hexarelin
    Outcome
    Not applicableApparent permeability coefficient of hexarelin
    Study

    ratn: not reported in source

    excised jejunal segments in diffusion chambers
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Papp
    18.87 x10(-7) cm/s
    hexarelin, rat jejunum

    Source sentences

    Summary
    Permeability coefficients (P(app)) were 18.87 +/- 2.86 (x10(-7) cm/s) and 5.87 +/- 0.45 (x10(-7) cm/s) for hexarelin and EP 51389, respectively.
    1 context sentence
    Summary · context
    The intestinal permeability of hexarelin and EP 51389, two growth hormone releasing hexa- and tri- peptide analogues, was assessed in vitro with side-by-side diffusion chambers in the apical-to-basolateral (AP-to-BL) and in the basolateral-to-apical (BL-to-AP) direction using excised rat jejunal segments.
  3. 03LabEx vivo tissuePharmacokinetics

    Hexarelin transport across rat jejunum was similar in the apical-to-basolateral and basolateral-to-apical directions.

    In plain wordsIn lab tests on rat gut tissue, hexarelin moved across the intestinal wall equally well in both directions.

    Peptide
    Hexarelin
    Outcome
    No significant changeDirection of hexarelin transport
    Study

    ratn: not reported in source

    excised jejunal segments in diffusion chambers
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bidirectional studies revealed that hexarelin transport was similar in both directions.
    1 context sentence
    Summary · context
    The intestinal permeability of hexarelin and EP 51389, two growth hormone releasing hexa- and tri- peptide analogues, was assessed in vitro with side-by-side diffusion chambers in the apical-to-basolateral (AP-to-BL) and in the basolateral-to-apical (BL-to-AP) direction using excised rat jejunal segments.

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 04LabNot a test of Hexarelin aloneEx vivo tissuePharmacokinetics

    EDTA did not influence hexarelin permeability across rat jejunum.

    In plain wordsIn lab tests on rat gut tissue, EDTA did not change how much hexarelin crossed the intestinal wall.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of EDTA on hexarelin permeability
    Study

    ratn: not reported in source

    excised jejunal segments in diffusion chambers
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    EDTA did not influence hexarelin permeability.
    1 context sentence
    Summary · context
    The intestinal permeability of hexarelin and EP 51389, two growth hormone releasing hexa- and tri- peptide analogues, was assessed in vitro with side-by-side diffusion chambers in the apical-to-basolateral (AP-to-BL) and in the basolateral-to-apical (BL-to-AP) direction using excised rat jejunal segments.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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