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Study · Randomized controlled trial · n = 132 · 2001

11 results

Effect of reduced dose of triptorelin at the start of ovarian stimulation on the outcome of IVF: a randomized study.

Dal Prato L, Borini A, Trevisi MR, Bonu MA, Sereni E, Flamigni C

Human reproduction (Oxford, England)1 Jul 2001Cited by 27 (Europe PMC)

PMID11425821 (opens in a new tab)DOI10.1093/humrep/16.7.1409 (opens in a new tab)PepBankPUB-11425821
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. 11 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In IVF patients, pregnancy rates per transfer did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, pregnancy rates per transfer did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePregnancy rate per transfer
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Measurements

    Pregnancy rate per transfer
    34.9%
    group 2
    Pregnancy rate per transfer
    38%
    group 1

    Source sentences

    Summary
    No significant differences were found in terms of pregnancy rate per transfer (38% in group 1 versus 34.9% in group 2), implantation rate (20.2 versus 18%) and abortion rate (8.3 versus 9.1%).
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In IVF patients, implantation rates did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, implantation rates did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeImplantation rate
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Measurements

    Implantation rate
    18%
    group 2
    Implantation rate
    20.2%
    group 1

    Source sentences

    Summary
    No significant differences were found in terms of pregnancy rate per transfer (38% in group 1 versus 34.9% in group 2), implantation rate (20.2 versus 18%) and abortion rate (8.3 versus 9.1%).
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  3. 03HumanRandomized controlled trialSafety outcome

    In IVF patients, abortion rates did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, abortion rates did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeAbortion rate
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Measurements

    Abortion rate
    9.1%
    group 2
    Abortion rate
    8.3%
    group 1

    Source sentences

    Summary
    No significant differences were found in terms of pregnancy rate per transfer (38% in group 1 versus 34.9% in group 2), implantation rate (20.2 versus 18%) and abortion rate (8.3 versus 9.1%).
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  4. 04HumanRandomized controlled trialEfficacy outcome

    In IVF patients, reduced-dose triptorelin required fewer FSH ampoules than depot triptorelin.

    In plain wordsIn IVF patients, reduced-dose triptorelin required fewer FSH ampoules than depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFSH ampoules used
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Measurements

    FSH ampoules
    41 ampoules
    group 2
    FSH ampoules
    46.6 ampoules
    group 1

    Source sentences

    Summary
    The number of FSH ampoules used, as well as the number of days stimulation required, was significantly reduced in group 2 (41 +/- 26 versus 46.6 +/- 25.3, P < 0.03 and 11 +/- 1.3 versus 11.8 +/- 1.5, P < 0.002 respectively).
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  5. 05HumanRandomized controlled trialEfficacy outcome

    In IVF patients, reduced-dose triptorelin required fewer stimulation days than depot triptorelin.

    In plain wordsIn IVF patients, reduced-dose triptorelin required fewer stimulation days than depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseStimulation duration
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Measurements

    Stimulation duration
    11 days
    group 2
    Stimulation duration
    11.8 days
    group 1

    Source sentences

    Summary
    The number of FSH ampoules used, as well as the number of days stimulation required, was significantly reduced in group 2 (41 +/- 26 versus 46.6 +/- 25.3, P < 0.03 and 11 +/- 1.3 versus 11.8 +/- 1.5, P < 0.002 respectively).
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  6. 06HumanRandomized controlled trialEfficacy outcome

    In IVF patients, oestradiol concentrations did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, oestradiol concentrations did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOestradiol concentrations
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Source sentences

    Summary
    No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  7. 07HumanRandomized controlled trialEfficacy outcome

    In IVF patients, follicle counts did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, follicle counts did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFollicle number
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Source sentences

    Summary
    No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  8. 08HumanRandomized controlled trialEfficacy outcome

    In IVF patients, collected oocyte counts did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, collected oocyte counts did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOocytes collected
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Source sentences

    Summary
    No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  9. 09HumanRandomized controlled trialEfficacy outcome

    In IVF patients, fertilized oocyte counts did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, fertilized oocyte counts did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOocytes fertilized
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Source sentences

    Summary
    No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  10. 10HumanRandomized controlled trialEfficacy outcome

    In IVF patients, obtained embryo counts did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, obtained embryo counts did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeEmbryos obtained
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Source sentences

    Summary
    No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…
  11. 11HumanRandomized controlled trialEfficacy outcome

    In IVF patients, transferred embryo counts did not differ significantly between reduced-dose and depot triptorelin.

    In plain wordsIn IVF patients, transferred embryo counts did not differ significantly between reduced-dose and depot triptorelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeEmbryos transferred
    Study

    n = 132

    Comparator
    Single 3.75 mg intramuscular depot triptorelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 microg daily reduced to 50 microg at FSH stimulationAs given in this study (human).

    Source sentences

    Summary
    No significant differences were seen in oestradiol concentrations and in follicle number, in the quantity of oocytes collected and fertilized, or in the number of embryos obtained or transferred.
    1 context sentence
    Summary · context
    A total of 132 patients was randomized in two groups. Pituitary desensitization was obtained in group 1 (66 patients) with a single 3.75 mg injection (i.m.) of triptorelin. In group 2, 66 patients received 100 microg triptorelin daily, which was then reduced to 50 microg at the start of follicle-sti…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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