In mice with carrageenin-induced paw edema, the Phe(4F)12 analog of deacetyl-thymosin beta4 had a markedly stronger anti-inflammatory effect than the parent synthetic deacetyl-thymosin beta4.
In plain wordsIn mice, one lab-made Tbeta4 analog reduced paw swelling more than the parent compound did.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseAnti-inflammatory effect on carrageenin-induced paw edema
- Study
mousen: not reported in source
Carrageenin-induced paw edema- Comparator
- [Met(0)6]deacetyl-thymosin beta4
- Outcome group
- Inflammation markers · Immune and inflammation
Source sentences
Fluorination of the para-position of Phe12 resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic [Met(0)6]deacetyl-thymosin beta4
1 context sentence(design, population, supporting numbers)
Two [Met(0)6]deacetyl-thymosin beta4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).