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Study · Ex vivo tissue · 2001

8 results

Actions of gonadotropin-releasing hormone antagonists on steroidogenesis in human granulosa lutein cells.

Weiss JM, Oltmanns K, Gürke EM, Polack S, Eick F, Felberbaum R, Diedrich K, Ortmann O

European journal of endocrinology1 Jun 2001Cited by 33 (Europe PMC)

PMID11375803 (opens in a new tab)DOI10.1530/eje.0.1440677 (opens in a new tab)PepBankPUB-11375803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In lab tests, cells from ganirelix-treated patients showed no significant effect of prior treatment on spontaneous steroidogenesis.

    In plain wordsIn lab tests, ovarian cells from ganirelix-treated patients had similar spontaneous steroid production to cells from patients receiving no GnRH analogue.

    Peptide
    Ganirelix
    Outcome
    No significant changeSpontaneous steroidogenesis after patient treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Comparator
    No GnRH analogue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Such in vivo treatment did not result in significant effects of triptorelin or the two GnRH antagonists on spontaneous or human chorionic gonadotropin (hCG)-stimulated steroidogenesis.
    2 context sentences
    Summary · context
    Cells were obtained from patients treated with different protocols of COH. In addition to gonadotropins they received triptorelin, cetrorelix, ganirelix or no GnRH analogue.
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.
  2. 02LabEx vivo tissueActivity measurement

    In lab tests, cells from ganirelix-treated patients showed no significant effect of prior treatment on hCG-stimulated steroidogenesis.

    In plain wordsIn lab tests, ovarian cells from ganirelix-treated patients had similar hormone-stimulated steroid production to cells from patients receiving no GnRH analogue.

    Peptide
    Ganirelix
    Outcome
    No significant changehCG-stimulated steroidogenesis after patient treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Comparator
    No GnRH analogue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Such in vivo treatment did not result in significant effects of triptorelin or the two GnRH antagonists on spontaneous or human chorionic gonadotropin (hCG)-stimulated steroidogenesis.
    2 context sentences
    Summary · context
    Cells were obtained from patients treated with different protocols of COH. In addition to gonadotropins they received triptorelin, cetrorelix, ganirelix or no GnRH analogue.
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.
  3. 03LabIn vitro (cells)Mechanism

    In cultured human granulosa lutein cells, prior triptorelin treatment did not significantly affect spontaneous steroidogenesis.

    In plain wordsIn cells, prior triptorelin treatment did not significantly affect spontaneous steroid production.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeSpontaneous steroidogenesis after in vivo treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Such in vivo treatment did not result in significant effects of triptorelin or the two GnRH antagonists on spontaneous or human chorionic gonadotropin (hCG)-stimulated steroidogenesis.
    1 context sentence
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.MethodsCells were obtained from patients treated with different protocols of COH. In addition to gonad…
  4. 04LabIn vitro (cells)Mechanism

    In cultured human granulosa lutein cells, prior triptorelin treatment did not significantly affect hCG-stimulated steroidogenesis.

    In plain wordsIn cells, prior triptorelin treatment did not significantly affect hCG-stimulated steroid production.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changehCG-stimulated steroidogenesis after in vivo treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Such in vivo treatment did not result in significant effects of triptorelin or the two GnRH antagonists on spontaneous or human chorionic gonadotropin (hCG)-stimulated steroidogenesis.
    1 context sentence
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.MethodsCells were obtained from patients treated with different protocols of COH. In addition to gonad…
  5. 05LabIn vitro (cells)Mechanism

    In cultured human granulosa lutein cells, in vitro triptorelin treatment did not affect basal steroid production.

    In plain wordsIn cells, triptorelin treatment in vitro did not affect basal steroid production.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeBasal steroid production after in vitro treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · Up to 96 hAs given in this study (human).

    Source sentences

    Summary
    However, these treatment paradigms did not influence basal or hCG-stimulated steroid production.
    2 context sentences
    Summary · context
    To exclude the possibility that the in vivo treatment might not affect in vitro steroid production because of low or absent peptide activity, we performed in vitro treatments with triptorelin, cetrorelix and ganirelix for up to 96 h.
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.MethodsCells were obtained from patients treated with different protocols of COH. In addition to gonad…
  6. 06LabIn vitro (cells)Mechanism

    In cultured human granulosa lutein cells, in vitro triptorelin treatment did not affect hCG-stimulated steroid production.

    In plain wordsIn cells, triptorelin treatment in vitro did not affect hCG-stimulated steroid production.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changehCG-stimulated steroid production after in vitro treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · Up to 96 hAs given in this study (human).

    Source sentences

    Summary
    However, these treatment paradigms did not influence basal or hCG-stimulated steroid production.
    2 context sentences
    Summary · context
    To exclude the possibility that the in vivo treatment might not affect in vitro steroid production because of low or absent peptide activity, we performed in vitro treatments with triptorelin, cetrorelix and ganirelix for up to 96 h.
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.MethodsCells were obtained from patients treated with different protocols of COH. In addition to gonad…
  7. 07LabIn vitro (cells)Activity measurement

    In cultured human granulosa lutein cells, ganirelix treatment for up to 96 h did not influence basal steroid production.

    In plain wordsIn cells, ganirelix treatment for up to 96 h did not change basal steroid production.

    Peptide
    Ganirelix
    Outcome
    No significant changeBasal steroid production during direct treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 96 hAs given in this study (human).

    Source sentences

    Summary
    However, these treatment paradigms did not influence basal or hCG-stimulated steroid production.
    2 context sentences
    Summary · context
    To exclude the possibility that the in vivo treatment might not affect in vitro steroid production because of low or absent peptide activity, we performed in vitro treatments with triptorelin, cetrorelix and ganirelix for up to 96 h.
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.
  8. 08LabIn vitro (cells)Activity measurement

    In cultured human granulosa lutein cells, ganirelix treatment for up to 96 h did not influence hCG-stimulated steroid production.

    In plain wordsIn cells, ganirelix treatment for up to 96 h did not change hormone-stimulated steroid production.

    Peptide
    Ganirelix
    Outcome
    No significant changehCG-stimulated steroid production during direct treatment
    Study

    humann: not reported in source

    Cultured human granulosa lutein cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 96 hAs given in this study (human).

    Source sentences

    Summary
    However, these treatment paradigms did not influence basal or hCG-stimulated steroid production.
    2 context sentences
    Summary · context
    To exclude the possibility that the in vivo treatment might not affect in vitro steroid production because of low or absent peptide activity, we performed in vitro treatments with triptorelin, cetrorelix and ganirelix for up to 96 h.
    Summary · context
    Since there is some controversy about the action of GnRH agonists in the human ovary we also tested the effect of triptorelin on steroid production in cultured human granulosa lutein cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    27 Oct 2026, 16:35 UTC

    The same notice was added 2 times, first on 27 Oct 2026, 16:35 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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