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Study · Animal study (in vivo) · rhesus macaque · 2001

2 results

Central melanocortin receptors mediate changes in food intake in the rhesus macaque.

Koegler FH, Grove KL, Schiffmacher A, Smith MS, Cameron JL

Endocrinology1 Jun 2001Cited by 44 (Europe PMC)

PMID11356708 (opens in a new tab)DOI10.1210/endo.142.6.8198 (opens in a new tab)PepBankPUB-11356708
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus macaques, infusion of NDP-MSH into the lateral cerebral ventricle dose dependently suppressed intake of a normally scheduled meal.

    In plain wordsIn rhesus macaques, NDP-MSH infused into the brain reduced meal intake in a dose-dependent way.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseIntake of scheduled meal
    Study

    rhesus macaquen: not reported in source

    in vivo, adult male rhesus macaques
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricular (lateral cerebral ventricle)As given in this study (rhesus macaque).

    Source sentences

    Summary
    Infusion of NDP-MSH into the lateral cerebral ventricle dose dependently suppressed intake of a normally scheduled meal without affecting nonfeeding behaviors.
    1 context sentence
    Summary · context
    This report describes the effects of the stable alphaMSH analog, NDP-MSH ([Nle(4), D-Phe(7)]alphaMSH), and the endogenous alphaMSH receptor antagonist, agouti-related protein, on feeding behavior in adult male rhesus macaques.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rhesus macaques, intraventricular NDP-MSH did not affect nonfeeding behaviors.

    In plain wordsIn rhesus macaques, NDP-MSH infused into the brain did not change behaviors other than feeding.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeNonfeeding behaviors
    Study

    rhesus macaquen: not reported in source

    in vivo, adult male rhesus macaques
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricular (lateral cerebral ventricle)As given in this study (rhesus macaque).

    Source sentences

    Summary
    Infusion of NDP-MSH into the lateral cerebral ventricle dose dependently suppressed intake of a normally scheduled meal without affecting nonfeeding behaviors.
    1 context sentence
    Summary · context
    This report describes the effects of the stable alphaMSH analog, NDP-MSH ([Nle(4), D-Phe(7)]alphaMSH), and the endogenous alphaMSH receptor antagonist, agouti-related protein, on feeding behavior in adult male rhesus macaques.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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