Sex hormone replacement therapy reverses decreased venous distensibility in pharmacologically ovariectomized rats.

Várbíró S, Nádasy GL, Monos E, Acs N, Vajo Z, Székács B

Menopause (New York, N.Y.)1 May 2001Cited by 7 (Europe PMC)

PMID11355043DOI10.1097/00042192-200105000-00010PepBankPUB-11355043

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In female rats, triptorelin-induced ovariectomy was reported to lower contracted venous distensibility compared with controls.
In plain wordsIn female rats, triptorelin-induced ovariectomy was reported to lower contracted venous distensibility compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseContracted venous distensibility after ovariectomy
Study
Sprague-Dawley ratn: not reported in source
Pharmacological ovariectomy
Comparator
Controls without pharmacological ovariectomy
Outcome group
Vascular function · Cardiovascular
Source sentences
Summary
Pharmacological ovariectomy lowered venous wall distensibility measured in contraction (at P=8 mm Hg: 4.41+/-1.21*10(-3) m2/N vs. control: 0.79+/-0.14*10(-3) m2/N; p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty Sprague-Dawley rats were pharmacologically ovariectomized by triptorelin. Ten of these animals received combined hormone replacement with estradiol and medroxyprogesterone acetate. The rest were given vehicle. Ten animals kept parallel without pharmacological ovariectomy served as controls. A…
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1135504301
02AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-treated female rats, estradiol and medroxyprogesterone partially restored contracted venous distensibility compared with vehicle.
In plain wordsIn triptorelin-treated female rats, hormone replacement partially restored contracted venous distensibility compared with vehicle.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseHormone replacement and contracted distensibility
Study
Sprague-Dawley ratn: not reported in source
Pharmacological ovariectomy
Comparator
Pharmacological ovariectomy with vehicle
Outcome group
Vascular function · Cardiovascular
Source sentences
Summary
Hormone replacement partially restored this value (1.8+/-0.49*10(-3) m2/N).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty Sprague-Dawley rats were pharmacologically ovariectomized by triptorelin. Ten of these animals received combined hormone replacement with estradiol and medroxyprogesterone acetate. The rest were given vehicle. Ten animals kept parallel without pharmacological ovariectomy served as controls. A…
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1135504302
03AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In the female rat ovariectomy study, relaxed venous distensibility showed no alterations.
In plain wordsIn the female rat ovariectomy study, relaxed venous distensibility showed no alterations.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeRelaxed venous distensibility
Study
Sprague-Dawley ratn: not reported in source
Pharmacological ovariectomy
Comparator
Controls
Outcome group
Vascular function · Cardiovascular
Source sentences
Summary
No alterations in distensibility were found in the relaxed state.
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty Sprague-Dawley rats were pharmacologically ovariectomized by triptorelin. Ten of these animals received combined hormone replacement with estradiol and medroxyprogesterone acetate. The rest were given vehicle. Ten animals kept parallel without pharmacological ovariectomy served as controls. A…
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1135504303
04AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In female rats, pharmacological ovariectomy reduced body-weight-adjusted venous inner radius compared with controls.
In plain wordsIn female rats, pharmacological ovariectomy reduced weight-adjusted venous inner radius compared with controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseVenous inner radius after ovariectomy
Study
Sprague-Dawley ratn: not reported in source
Pharmacological ovariectomy
Comparator
Controls without pharmacological ovariectomy
Outcome group
Vascular function · Cardiovascular
Source sentences
Summary
After adjusting for body weight, we found that pharmacological ovariectomy lowered venous inner radius significantly compared with control (p < 0.05),
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty Sprague-Dawley rats were pharmacologically ovariectomized by triptorelin. Ten of these animals received combined hormone replacement with estradiol and medroxyprogesterone acetate. The rest were given vehicle. Ten animals kept parallel without pharmacological ovariectomy served as controls. A…
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1135504304
05AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-treated female rats, hormone replacement increased venous inner radius compared with pharmacological ovariectomy alone.
In plain wordsIn triptorelin-treated female rats, hormone replacement increased venous inner radius compared with pharmacological ovariectomy alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseHormone replacement and radius versus ovariectomy
Study
Sprague-Dawley ratn: not reported in source
Pharmacological ovariectomy
Comparator
Pharmacological ovariectomy
Outcome group
Vascular function · Cardiovascular
Source sentences
Summary
whereas hormone replacement increased it compared with pharmacological ovariectomy (p < 0.05) and more significantly compared with control (p < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty Sprague-Dawley rats were pharmacologically ovariectomized by triptorelin. Ten of these animals received combined hormone replacement with estradiol and medroxyprogesterone acetate. The rest were given vehicle. Ten animals kept parallel without pharmacological ovariectomy served as controls. A…
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1135504305
06AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism
In triptorelin-treated female rats, hormone replacement increased venous inner radius compared with controls without pharmacological ovariectomy.
In plain wordsIn triptorelin-treated female rats, hormone replacement increased venous inner radius compared with controls without pharmacological ovariectomy.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseHormone replacement and radius versus control
Study
Sprague-Dawley ratn: not reported in source
Pharmacological ovariectomy
Comparator
Controls without pharmacological ovariectomy
Outcome group
Vascular function · Cardiovascular
Source sentences
Summary
whereas hormone replacement increased it compared with pharmacological ovariectomy (p < 0.05) and more significantly compared with control (p < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Twenty Sprague-Dawley rats were pharmacologically ovariectomized by triptorelin. Ten of these animals received combined hormone replacement with estradiol and medroxyprogesterone acetate. The rest were given vehicle. Ten animals kept parallel without pharmacological ovariectomy served as controls. A…
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-1135504306

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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