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Study · In vitro (cells) · 2001

5 results

Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.

Hashimoto Y, Ito Y, Niikura T, Shao Z, Hata M, Oyama F, Nishimoto I

Biochemical and biophysical research communications1 May 2001Cited by 185 (Europe PMC)

PMID11327724 (opens in a new tab)DOI10.1006/bbrc.2001.4765 (opens in a new tab)PepBankPUB-11327724
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    Treatment of neuronal cells with the HN polypeptide abrogated cytotoxicity caused by the Swedish mutant NL-APP.

    In plain wordsIn cells, treatment with the humanin peptide stopped nerve cell death caused by a mutant Alzheimer's-related protein.

    Peptide
    Humanin
    Outcome
    DecreaseNL-APP cytotoxicity after HN polypeptide treatment
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transfection of neuronal cells with HN cDNA or treatment with the coding HN polypeptide abrogated cytotoxicity by NL-APP.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 02LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    Transfection of neuronal cells with HN cDNA abrogated cytotoxicity caused by the Swedish mutant NL-APP.

    In plain wordsIn cells, adding the humanin gene stopped nerve cell death caused by a mutant Alzheimer's-related protein.

    Peptide
    Humanin
    Outcome
    DecreaseNL-APP cytotoxicity after HN cDNA transfection
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Transfection of neuronal cells with HN cDNA or treatment with the coding HN polypeptide abrogated cytotoxicity by NL-APP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 03LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    HN suppressed neurotoxicity by Abeta1-43 in the absence of N2 supplement.

    In plain wordsIn cells, humanin reduced amyloid-beta toxicity to nerve cells when a growth supplement was missing.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta1-43 neurotoxicity without N2 supplement
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HN suppressed neurotoxicity by Abeta1-43 in the absence of N2 supplement

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 04LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    HN could not inhibit Abeta secretion from NL-APP.

    In plain wordsIn cells, humanin did not reduce the release of amyloid-beta from cells with the mutant protein.

    Peptide
    Humanin
    Outcome
    No significant changeAbeta secretion from NL-APP cells
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    but could not inhibit Abeta secretion from NL-APP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 05LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    HN protected neuronal cells from death caused by NL-APP that lacks the 41st and 42nd residues of the Abeta region.

    In plain wordsIn cells, humanin protected nerve cells from a mutant protein that lacks part of the amyloid-beta region.

    Peptide
    Humanin
    Outcome
    DecreaseCell death by NL-APP lacking residues 41 and 42 of the Abeta region
    Study

    n: not reported in source

    neuronal cells
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    HN could also protect neuronal cells from death by NL-APP lacking the 41st and 42nd residues of the Abeta region.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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