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Study · Animal study (in vivo) · rat · 2001

2 results

Do growth hormone-releasing peptides act as ghrelin secretagogues?

Ahnfelt-Rønne I, Nowak J, Olsen UB

Endocrine1 Feb 2001Cited by 4 (Europe PMC)

PMID11322495 (opens in a new tab)DOI10.1385/endo:14:1:133 (opens in a new tab)PepBankPUB-11322495
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats given radiolabeled GHRP‑6 intravenously, a substantial amount accumulated in the glandular part of the stomach.

    In plain wordsIn rats, a large amount of GHRP‑6 collected in the part of the stomach that makes ghrelin.

    Peptide
    GHRP-6
    Outcome
    Not applicableAccumulation in glandular stomach
    Study

    ratn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    When the disposition in rats of NN703 and GHRP-6 was studied using whole-body autoradiography following administration of an iv dose of radiolabeled material, we found that a substantial amount of these secretagogues accumulate in the glandular part of the stomach.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In rats, resection of the gastrointestinal tract attenuated the GH response to GHRP‑6 by 60-70%.

    In plain wordsIn rats, removing part of the gut reduced the growth hormone response to GHRP‑6 by 60 to 70%.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH secretion response after GI tract resection
    Study

    ratn: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Attenuation of GH response
    60 to 70%
    after GI tract resection

    Source sentences

    Summary
    Because this is the site of synthesis and secretion of ghrelin, the endogenous GHS, we investigated the effect of resection of the gastrointestinal (GI) tract on growth hormone (GH) release induced by GHRP-6. This procedure significantly attenuated the GH secretion response by 60-70%.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 36Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 34 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:13 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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