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Study · Animal study (in vivo) · rat · 2001

5 results

Hexarelin, but not growth hormone, protects heart from damage induced in vitro by calcium deprivation replenishment.

Torsello A, Rossoni G, Locatelli V, De Gennaro Colonna V, Bernareggi M, Francolini M, Müller EE, Berti F

Endocrine1 Feb 2001Cited by 5 (Europe PMC)

PMID11322492 (opens in a new tab)DOI10.1385/endo:14:1:109 (opens in a new tab)PepBankPUB-11322492
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, 7 days of subcutaneous hexarelin antagonized the sudden rise in resting tension of isolated hearts on calcium repletion.

    In plain wordsIn rats, a week of hexarelin injections limited the rise in heart resting tension after calcium was restored.

    Peptide
    Hexarelin
    Outcome
    DecreaseResting tension increase on Ca2+ repletion after 7 days of hexarelin
    Study

    ratn: not reported in source

    isolated perfused hearts, calcium paradox
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    80 microg/kg bid · subcutaneous · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Hexarelin (80 microg/kg bid, subcutaneously) administered for 7 d to male rats effectively antagonized the sudden increase in resting tension measured in vitro on Ca2+ repletion.
    1 context sentence
    Summary · context
    The effects of hexarelin, a growth hormone (GH) secretagogue, and human GH on the mechanical and metabolic changes measured in isolated rat hearts submitted to 5 min of Ca2+ deprivation followed by reperfusion with Ca2+-containing medium, the so-called calcium paradox phenomenon, were studied.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, 7 days of hexarelin reduced creatine kinase release from isolated hearts during calcium repletion by up to 40% compared with controls.

    In plain wordsIn rats, a week of hexarelin injections reduced a marker of heart cell damage by up to 40% compared with controls.

    Peptide
    Hexarelin
    Outcome
    DecreaseCreatine kinase release during Ca2+ repletion after 7 days of hexarelin
    Study

    ratn: not reported in source

    isolated perfused hearts, calcium paradox
    Comparator
    Controls
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    80 microg/kg bid · subcutaneous · 7 daysAs given in this study (rat).

    Measurements

    creatine kinase release reduction
    ≤ 40%
    hexarelin 7 d vs controls

    Source sentences

    Summary
    Moreover, during Ca2+ repletion the release of creatine kinase activity (an index of cell damage) in the perfusate of these hearts was reduced up to 40% compared with controls.
    2 context sentences
    Summary · context
    Hexarelin (80 microg/kg bid, subcutaneously) administered for 7 d to male rats effectively antagonized the sudden increase in resting tension measured in vitro on Ca2+ repletion.
    Summary · context
    The effects of hexarelin, a growth hormone (GH) secretagogue, and human GH on the mechanical and metabolic changes measured in isolated rat hearts submitted to 5 min of Ca2+ deprivation followed by reperfusion with Ca2+-containing medium, the so-called calcium paradox phenomenon, were studied.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, 3 days of hexarelin did not affect the mechanical and metabolic alterations induced by the calcium paradox in isolated hearts.

    In plain wordsIn rats, 3 days of hexarelin did not protect isolated hearts from the damage caused by the calcium paradox.

    Peptide
    Hexarelin
    Outcome
    No significant changeCalcium paradox alterations after 3 days of hexarelin
    Study

    ratn: not reported in source

    isolated perfused hearts, calcium paradox
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    Dose not stated · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    administration of hexarelin for 3 d or GH (400 microg/kg bid, subcutaneously) for 7 d did not affect the mechanical and metabolic alterations induced by the calcium paradox
    1 context sentence
    Summary · context
    The effects of hexarelin, a growth hormone (GH) secretagogue, and human GH on the mechanical and metabolic changes measured in isolated rat hearts submitted to 5 min of Ca2+ deprivation followed by reperfusion with Ca2+-containing medium, the so-called calcium paradox phenomenon, were studied.
  4. 04LabEx vivo tissueEfficacy outcome

    In isolated hearts of normal rats, acute perfusion of hexarelin did not stimulate heart contractility.

    In plain wordsIn isolated rat hearts, hexarelin given directly for 60 minutes did not increase contractility.

    Peptide
    Hexarelin
    Outcome
    No significant changeHeart contractility with acute hexarelin perfusion
    Study

    ratn: not reported in source

    isolated perfused hearts, calcium paradox
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    8 microg/mL · in vitro perfusion · 60 minAs given in this study (rat).

    Source sentences

    Summary
    hexarelin did not stimulate heart contractility
    2 context sentences
    Summary · context
    To assess its direct and acute cardiac effects, hexarelin (8 microg/mL) was perfused in vitro in recirculating conditions for 60 min through the hearts of normal rats.
    Summary · context
    The effects of hexarelin, a growth hormone (GH) secretagogue, and human GH on the mechanical and metabolic changes measured in isolated rat hearts submitted to 5 min of Ca2+ deprivation followed by reperfusion with Ca2+-containing medium, the so-called calcium paradox phenomenon, were studied.
  5. 05LabEx vivo tissueEfficacy outcome

    In isolated hearts of normal rats, acute perfusion of hexarelin failed to prevent ventricular contracture on calcium readmission.

    In plain wordsIn isolated rat hearts, hexarelin given directly did not prevent the stiffening that follows calcium readmission.

    Peptide
    Hexarelin
    Outcome
    No significant changeVentricular contracture on Ca2+ readmission with acute hexarelin perfusion
    Study

    ratn: not reported in source

    isolated perfused hearts, calcium paradox
    Outcome group
    Myocardial injury · Cardiovascular
    Studied dose
    8 microg/mL · in vitro perfusion · 60 minAs given in this study (rat).

    Source sentences

    Summary
    failed to prevent ventricular contracture upon Ca2+ readmission
    2 context sentences
    Summary · context
    To assess its direct and acute cardiac effects, hexarelin (8 microg/mL) was perfused in vitro in recirculating conditions for 60 min through the hearts of normal rats.
    Summary · context
    The effects of hexarelin, a growth hormone (GH) secretagogue, and human GH on the mechanical and metabolic changes measured in isolated rat hearts submitted to 5 min of Ca2+ deprivation followed by reperfusion with Ca2+-containing medium, the so-called calcium paradox phenomenon, were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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