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Study · Animal study (in vivo) · rat · 2001

8 results

Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model.

Roth C, Schricker M, Lakomek M, Strege A, Heiden I, Luft H, Munzel U, Wuttke W, Jarry H

The Journal of endocrinology1 May 2001Cited by 48 (Europe PMC)

PMID11312152 (opens in a new tab)DOI10.1677/joe.0.1690361 (opens in a new tab)PepBankPUB-11312152
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In female rats, triptorelin delayed puberty onset compared with placebo.

    In plain wordsIn female rats, triptorelin delayed puberty onset compared with placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOnset of puberty
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10 or 100 microgram/day · Postnatal days 25-36As given in this study (rat).

    Source sentences

    Summary
    Onset of puberty was retarded by both analogs
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In female rats, low-dose triptorelin increased serum gonadotropins compared with placebo.

    In plain wordsIn female rats, low-dose triptorelin increased serum gonadotropins compared with placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSerum gonadotropins at low dose
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10 microgram/day · Postnatal days 25-36As given in this study (rat).

    Source sentences

    Summary
    Onset of puberty was retarded by both analogs but CET (100 microgram/day) inhibited while TRIP (10 and 100 microgram/day) stimulated serum gonadotropins (P<0.05).
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In female rats, high-dose triptorelin increased serum gonadotropins compared with placebo.

    In plain wordsIn female rats, high-dose triptorelin increased serum gonadotropins compared with placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSerum gonadotropins at high dose
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microgram/day · Postnatal days 25-36As given in this study (rat).

    Source sentences

    Summary
    Onset of puberty was retarded by both analogs but CET (100 microgram/day) inhibited while TRIP (10 and 100 microgram/day) stimulated serum gonadotropins (P<0.05).
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In female rats, triptorelin increased pituitary GnRH receptor mRNA compared with placebo.

    In plain wordsIn female rats, triptorelin increased pituitary GnRH receptor gene expression compared with placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePituitary GnRH receptor mRNA
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10 microgram/day · Postnatal days 25-36As given in this study (rat).

    Source sentences

    Summary
    whereas in the pituitary GnRH-receptor mRNA levels were stimulated by TRIP (10 microgram/day) but inhibited by CET (100 microgram/day).
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In female rats, triptorelin decreased ovarian GnRH receptor mRNA compared with placebo.

    In plain wordsIn female rats, triptorelin decreased ovarian GnRH receptor gene expression compared with placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseOvarian GnRH receptor mRNA
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microgram/day · Postnatal days 25-36As given in this study (rat).

    Source sentences

    Summary
    In contrast, in the ovary GnRH-receptor mRNA levels were inhibited by both TRIP (100 microgram/day) and CET (100 microgram/day).
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…
  6. 06AnimalAnimal study (in vivo)Mechanism

    In female rats, triptorelin increased uterine GnRH receptor expression in a dose-related manner compared with placebo.

    In plain wordsIn female rats, triptorelin increased uterine GnRH receptor expression in a dose-related manner compared with placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseUterine GnRH receptor expression
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    10 or 100 microgram/day · Postnatal days 25-36As given in this study (rat).

    Source sentences

    Summary
    Interestingly, the GnRH-receptor was even expressed in the uterus where it was strongly stimulated by both CET and TRIP in a dose-related manner.
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 07AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism

    In female rats, preoptic GnRH expression did not differ significantly among treatment groups, including triptorelin and placebo.

    In plain wordsIn female rats, preoptic GnRH expression did not differ significantly among treatment groups, including triptorelin and placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePreoptic GnRH expression
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    All treatment groups including placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The expression of GnRH in the preoptic area did not show significant differences among the treatment groups
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 08AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Mechanism

    In female rats, hypothalamic GnRH receptor expression did not vary among groups, including triptorelin and placebo.

    In plain wordsIn female rats, hypothalamic GnRH receptor expression did not vary among groups, including triptorelin and placebo.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeHypothalamic GnRH receptor expression
    Study

    ratn: not reported in source

    Prepubertal/peripubertal female rats
    Comparator
    All treatment groups including placebo
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The GnRH-receptor expression in the hypothalamus (preoptic area and mediobasal hypothalamus) did not vary among any of the groups,
    1 context sentence
    Summary · context
    To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH…

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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