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Study · Non-randomized trial · n = 42 · 2000

3 results

Serum inhibin A and inhibin B in central precocious puberty before and during treatment with GnRH agonists.

Sehested A, Andersson AM, Müller J, Skakkebaek NE

Hormone research1 Jan 2000Cited by 14 (Europe PMC)

PMID11251372 (opens in a new tab)DOI10.1159/000053237 (opens in a new tab)PepBankPUB-11251372
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In girls with central precocious puberty, triptorelin reduced inhibin B more than buserelin plus cyproterone acetate.

    In plain wordsIn girls with early puberty, triptorelin reduced inhibin B more than buserelin plus cyproterone acetate.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseInhibin B reduction versus buserelin plus cyproterone
    Study

    n = 42

    Comparator
    Intranasal buserelin plus oral cyproterone acetate
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · depot injectionAs given in this study (human).

    Measurements

    Inhibin B median
    < 20 pg/ml
    group 2, triptorelin depot
    Inhibin B median
    34.5 pg/ml
    group 1, buserelin plus cyproterone acetate

    Source sentences

    Summary
    There was a significantly (p = 0.003) greater fall in inhibin B levels during treatment in group 2 compared to group 1, with inhibin B levels now lying below (group 2: <20 pg/ml (<20--68)) rather than within (group 1: 34.5 pg/ml (<20--93)) the age-appropriate range.
    1 context sentence
    Summary · context
    During treatment with GnRH agonist (intranasal buserelin and oral cyproterone acetate, treatment group 1, n = 23, or triptorelin depot injections, treatment group 2, n = 19) levels of both hormones fell significantly (p = 0.002).

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In girls with central precocious puberty, inhibin A fell significantly during treatment with GnRH agonists (intranasal buserelin plus oral cyproterone acetate, or triptorelin depot injections), as reported for both treatment groups together.

    In plain wordsIn girls with early puberty, inhibin A fell during treatment with GnRH agonists (buserelin with cyproterone, or triptorelin), reported for both treatment groups together.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseInhibin A
    Study

    n = 42

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    During treatment with GnRH agonist (intranasal buserelin and oral cyproterone acetate, treatment group 1, n = 23, or triptorelin depot injections, treatment group 2, n = 19) levels of both hormones fell significantly (p = 0.002).

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome

    In girls with central precocious puberty, inhibin B fell significantly during treatment with GnRH agonists (intranasal buserelin plus oral cyproterone acetate, or triptorelin depot injections), as reported for both treatment groups together.

    In plain wordsIn girls with early puberty, inhibin B fell during treatment with GnRH agonists (buserelin with cyproterone, or triptorelin), reported for both treatment groups together.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseInhibin B
    Study

    n = 42

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    During treatment with GnRH agonist (intranasal buserelin and oral cyproterone acetate, treatment group 1, n = 23, or triptorelin depot injections, treatment group 2, n = 19) levels of both hormones fell significantly (p = 0.002).

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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