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Study · Randomized controlled trial · n = 7 · 2001

4 results

Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.

Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E

The Journal of clinical endocrinology and metabolism1 Mar 2001Cited by 322 (Europe PMC)

PMID11238504 (opens in a new tab)DOI10.1210/jcem.86.3.7314 (opens in a new tab)PepBankPUB-11238504
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In normal young volunteers, the GH response to hexarelin 1.0 microg/kg i.v. (Cmax 68.4 microg/L) was lower than the response to ghrelin.

    In plain wordsIn healthy young adults, hexarelin raised growth hormone, though less than ghrelin did.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin
    Study

    n = 7

    Comparator
    Ghrelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.0 microg/kg · intravenousAs given in this study (human).

    Measurements

    GH Cmax
    68.4 microg/L
    hexarelin
    GH AUC
    1546.9 microg/L x h
    hexarelin

    Source sentences

    Summary
    even significantly higher (P < 0.05) than after HEX (68.4 +/- 14.7 microg/L; 1546.9 +/- 380.0 microg/L x h)
    2 context sentences
    Summary · context
    Seven normal young volunteers (7 men; 24-32 yr old; body mass index, 20-24 kg/m(2)) were studied.
    Summary · context
    All subjects underwent the administration of ghrelin, HEX, and GHRH-29 (1.0 microg/kg i.v. at 0 min) as well as placebo (2 mL isotonic saline i.v. at 0 min).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In normal young volunteers, the PRL, ACTH and cortisol responses to hexarelin were lower than those elicited by ghrelin.

    In plain wordsIn healthy young adults, hexarelin raised prolactin, ACTH and cortisol less than ghrelin did.

    Peptide
    Hexarelin
    Outcome
    DecreasePRL, ACTH and cortisol responses to hexarelin
    Study

    n = 7

    Comparator
    Ghrelin
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.0 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Ghrelin administration also induced an increase in PRL, ACTH, and cortisol levels; these responses were higher (P < 0.05) than those elicited by HEX.
    2 context sentences
    Summary · context
    Seven normal young volunteers (7 men; 24-32 yr old; body mass index, 20-24 kg/m(2)) were studied.
    Summary · context
    All subjects underwent the administration of ghrelin, HEX, and GHRH-29 (1.0 microg/kg i.v. at 0 min) as well as placebo (2 mL isotonic saline i.v. at 0 min).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In normal young volunteers, aldosterone did not increase significantly after hexarelin, while it increased after ghrelin.

    In plain wordsIn healthy young adults, aldosterone did not rise after hexarelin, while it rose after ghrelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeAldosterone response to hexarelin
    Study

    n = 7

    Comparator
    Ghrelin
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    1.0 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    A significant increase in aldosterone levels was recorded after ghrelin but not after HEX.
    2 context sentences
    Summary · context
    Seven normal young volunteers (7 men; 24-32 yr old; body mass index, 20-24 kg/m(2)) were studied.
    Summary · context
    All subjects underwent the administration of ghrelin, HEX, and GHRH-29 (1.0 microg/kg i.v. at 0 min) as well as placebo (2 mL isotonic saline i.v. at 0 min).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In normal young volunteers, adding hexarelin to ghrelin did not change the endocrine responses to ghrelin.

    In plain wordsIn healthy young adults, giving hexarelin together with ghrelin did not change the hormone responses to ghrelin alone.

    Peptide
    Hexarelin
    Outcome
    No significant changeGhrelin endocrine responses with hexarelin coadministration
    Study

    n = 6

    Comparator
    Ghrelin alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.0 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    The endocrine responses to ghrelin were not modified by the coadministration of HEX.
    3 context sentences
    Summary · context
    Six subjects also underwent the combined administration of ghrelin and GHRH or HEX.
    Summary · context
    Seven normal young volunteers (7 men; 24-32 yr old; body mass index, 20-24 kg/m(2)) were studied.
    Summary · context
    All subjects underwent the administration of ghrelin, HEX, and GHRH-29 (1.0 microg/kg i.v. at 0 min) as well as placebo (2 mL isotonic saline i.v. at 0 min).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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