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Study · Measured the body's own peptide · 1999

1 result

Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs.

Iguchi K, Usami Y, Hirano K, Hamatake M, Shibata M, Ishida R

Biochemical pharmacology1 May 1999Cited by 29 (Europe PMC)

PMID11230797 (opens in a new tab)DOI10.1016/s0006-2952(99)00030-1 (opens in a new tab)PepBankPUB-11230797
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Mechanism

    In Molt-4 cells, thymosin beta4 was commonly decreased after apoptosis was induced by etoposide, ICRF-193 and neocarzinostatin.

    In plain wordsIn cells, the body's own thymosin beta4 fell when anticancer drugs caused cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta4 level during apoptosis
    Study

    humann: not reported in source

    Molt-4 cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Following the induction of apoptosis, a low molecular weight protein that was identified to be thymosin beta4 by HPLC analysis was commonly decreased, and the morphology of actin filaments changed into clump formations.
    1 context sentence
    Summary · context
    When Molt-4 cells were exposed to the antitumor drugs etoposide, meso-2,3-bis(3,5-dioxopiperazine-1-yl)butane (ICRF-193), and neocarzinostatin, they exhibited apoptotic cell death as determined by flow cytometry using fluorescein isothiocyanate (FITC)-labeled annexin V staining of phosphatidylserine…

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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