Dose-finding study for the use of long-acting gonadotrophin-releasing hormone analogues prior to ovarian stimulation for IVF.

Yim SF, Lok IH, Cheung LP, Briton-Jones CM, Chiu TT, Haines CJ

Human reproduction (Oxford, England)1 Mar 2001Cited by 16 (Europe PMC)

PMID11228217DOI10.1093/humrep/16.3.492PepBankPUB-11228217

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialEfficacy outcome
In IVF patients, conventional-dose triptorelin suppressed LH more than low-dose triptorelin at 2 weeks.
In plain wordsIn IVF patients, conventional-dose triptorelin lowered LH more than low-dose triptorelin at 2 weeks.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH at 2 weeks
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Measurements
LH
2.2 IU/l
conventional dose at 2 weeks
LH
3.5 IU/l
low dose at 2 weeks
Source sentences
Summary
Mean concentrations of LH were 2.2 +/- 1.0 and 1.1 +/- 0.6 IU/l in the conventional dose group and 3.5 +/- 5.5 and 2.7 +/- 1.9 IU/l in the low dose group (P < 0.05 at 2 and 3 weeks).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821701
02HumanRandomized controlled trialEfficacy outcome
In IVF patients, conventional-dose triptorelin suppressed LH more than low-dose triptorelin at 3 weeks.
In plain wordsIn IVF patients, conventional-dose triptorelin lowered LH more than low-dose triptorelin at 3 weeks.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH at 3 weeks
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Measurements
LH
1.1 IU/l
conventional dose at 3 weeks
LH
2.7 IU/l
low dose at 3 weeks
Source sentences
Summary
Mean concentrations of LH were 2.2 +/- 1.0 and 1.1 +/- 0.6 IU/l in the conventional dose group and 3.5 +/- 5.5 and 2.7 +/- 1.9 IU/l in the low dose group (P < 0.05 at 2 and 3 weeks).
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821702
03HumanRandomized controlled trialEfficacy outcome
In IVF patients, gonadotrophin doses did not differ significantly between conventional-dose and low-dose triptorelin.
In plain wordsIn IVF patients, gonadotrophin doses did not differ significantly between conventional-dose and low-dose triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeGonadotrophin dose
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Source sentences
Summary
There were no significant differences between the doses of gonadotrophins used, the number of oocytes and embryos available and the time to resumption of menses, nor in the pregnancy rates.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821703
04HumanRandomized controlled trialEfficacy outcome
In IVF patients, available oocyte counts did not differ significantly between conventional-dose and low-dose triptorelin.
In plain wordsIn IVF patients, available oocyte counts did not differ significantly between conventional-dose and low-dose triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeOocytes available
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Source sentences
Summary
There were no significant differences between the doses of gonadotrophins used, the number of oocytes and embryos available and the time to resumption of menses, nor in the pregnancy rates.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821704
05HumanRandomized controlled trialEfficacy outcome
In IVF patients, available embryo counts did not differ significantly between conventional-dose and low-dose triptorelin.
In plain wordsIn IVF patients, available embryo counts did not differ significantly between conventional-dose and low-dose triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeEmbryos available
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Source sentences
Summary
There were no significant differences between the doses of gonadotrophins used, the number of oocytes and embryos available and the time to resumption of menses, nor in the pregnancy rates.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821705
06HumanRandomized controlled trialEfficacy outcome
In IVF patients, time to menses did not differ significantly between conventional-dose and low-dose triptorelin.
In plain wordsIn IVF patients, time to menses did not differ significantly between conventional-dose and low-dose triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeTime to resumption of menses
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Source sentences
Summary
There were no significant differences between the doses of gonadotrophins used, the number of oocytes and embryos available and the time to resumption of menses, nor in the pregnancy rates.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821706
07HumanRandomized controlled trialEfficacy outcome
In IVF patients, pregnancy rates did not differ significantly between conventional-dose and low-dose triptorelin.
In plain wordsIn IVF patients, pregnancy rates did not differ significantly between conventional-dose and low-dose triptorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePregnancy rate
Study
n = 60
Comparator
Triptorelin 1.87 mg
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
3.75 mgAs given in this study (human).
Source sentences
Summary
There were no significant differences between the doses of gonadotrophins used, the number of oocytes and embryos available and the time to resumption of menses, nor in the pregnancy rates.
1 context sentence(design, population, supporting numbers)
Summary · context
Sixty patients were randomized to receive either 3.75 mg (conventional dose) or 1.87 mg (low dose) triptorelin prior to ovarian stimulation for IVF.
Report a problemFND-1122821707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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