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Study · Animal study (in vivo) · rat · 2000

4 results

The influence of sex and gonadectomy on the growth hormone and corticosterone response to hexarelin in the rat.

Sibilia V, Cocchi D, Pagani F, Pecile A, Netti C

Life sciences1 Dec 2000Cited by 2 (Europe PMC)

PMID11191647 (opens in a new tab)DOI10.1016/s0024-3205(00)00940-1 (opens in a new tab)PepBankPUB-11191647
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In middle-aged rats, the GH response to hexarelin was significantly higher in intact males than in intact females.

    In plain wordsIn middle-aged rats, hexarelin raised growth hormone more in males than in females.

    Peptide
    Hexarelin
    Outcome
    Not applicableGH response to hexarelin, intact males versus females
    Study

    ratn: not reported in source

    anesthetized middle-aged intact and gonadectomized rats
    Comparator
    intact females
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    80 microg/Kg · intracarotidAs given in this study (rat).

    Measurements

    GH AUC
    12,560 ng/ml.45 min
    intact males
    GH AUC
    4628 ng/ml.45 min
    intact females

    Source sentences

    Summary
    The GH stimulatory response to HEXA was gender-related since the GH increase was significantly (p < 0.001) higher in intact males (area under the curve, AUC= 12560 +/- 1784 ng/ml.45 min) than in females (AUC= 4628 +/- 257 ng/ml.45 min).
    1 context sentence
    Summary · context
    HEXA (80 microg/Kg) was administered intracarotid to anesthetized intact or gonadectomized male (ORC) and female (OVX) middle-aged rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In middle-aged rats, the sex difference in the GH response to hexarelin persisted after gonadectomy.

    In plain wordsIn middle-aged rats, the male and female difference in the growth hormone response to hexarelin stayed after removal of the gonads.

    Peptide
    Hexarelin
    Outcome
    Not applicableGH response to hexarelin after gonadectomy
    Study

    ratn: not reported in source

    anesthetized middle-aged intact and gonadectomized rats
    Comparator
    gonadectomized females
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    80 microg/Kg · intracarotidAs given in this study (rat).

    Measurements

    GH AUC
    11,980 ng/ml.45 min
    gonadectomized males
    GH AUC
    5539 ng/ml.45 min
    gonadectomized females

    Source sentences

    Summary
    This sex difference does not depend on circulating gonadal steroids since it persists in ORC (AUC = 11980 +/- 1136 ng/ml.45 min) and OVX (AUC = 5539 +/- 614 ng/ml.45 min) rats.
    1 context sentence
    Summary · context
    HEXA (80 microg/Kg) was administered intracarotid to anesthetized intact or gonadectomized male (ORC) and female (OVX) middle-aged rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, hexarelin increased corticosterone secretion, and the increase was significantly higher in gonadectomized than in intact males.

    In plain wordsIn male rats, hexarelin raised corticosterone, and more so after removal of the testes.

    Peptide
    Hexarelin
    Outcome
    IncreaseCorticosterone response to hexarelin in male rats
    Study

    ratn: not reported in source

    anesthetized middle-aged intact and gonadectomized rats
    Comparator
    intact males
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    80 microg/Kg · intracarotidAs given in this study (rat).

    Source sentences

    Summary
    in male rats that have low basal corticosterone levels, HEXA caused an increase in corticosterone secretion, which was significantly (p< 0.05) higher in ORC than in intact rats.
    1 context sentence
    Summary · context
    HEXA (80 microg/Kg) was administered intracarotid to anesthetized intact or gonadectomized male (ORC) and female (OVX) middle-aged rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In intact and ovariectomized female rats, the corticosterone increase caused by hexarelin was delayed.

    In plain wordsIn female rats, the corticosterone rise after hexarelin came later.

    Peptide
    Hexarelin
    Outcome
    IncreaseCorticosterone response to hexarelin in female rats
    Study

    ratn: not reported in source

    anesthetized middle-aged intact and gonadectomized rats
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    80 microg/Kg · intracarotidAs given in this study (rat).

    Source sentences

    Summary
    The increase in corticosterone secretion by HEXA both in intact and OVX females was delayed, probably due to the elevated initial corticosterone levels, which could have activated the glucocorticoid negative feedback.
    1 context sentence
    Summary · context
    HEXA (80 microg/Kg) was administered intracarotid to anesthetized intact or gonadectomized male (ORC) and female (OVX) middle-aged rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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