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Study · Non-randomized trial · n = 11 · 2001

5 results

The diagnosis of growth hormone deficiency (GHD) in successfully treated acromegalic patients.

Murray RD, Peacey SR, Rahim A, Toogood AA, Thorner MO, Shalet SM

Clinical endocrinology1 Jan 2001Cited by 21 (Europe PMC)

PMID11167924 (opens in a new tab)DOI10.1046/j.1365-2265.2001.01189.x (opens in a new tab)PepBankPUB-11167924
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In acromegalic patients treated with irradiation, 4 of 11 had a GH increment above 20 mU/l after hexarelin.

    In plain wordsIn treated acromegaly patients who had irradiation, hexarelin raised growth hormone clearly in 4 of 11 patients.

    Peptide
    Hexarelin
    Outcome
    MixedGH increment above 20 mU/l after hexarelin, group B
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 mcg/kg · intravenous bolusAs given in this study (human).

    Measurements

    GH increment after hexarelin
    > 20 mU/l
    Group B

    Source sentences

    Summary
    In group B only 4/11 achieved a DeltaGHHEX > 20 mU/l, 5/11 producing a response of < 2 mU/l.
    3 context sentences
    Summary · context
    Nineteen acromegalic patients, in whom mean serum GH levels below 5 mU/l have been achieved through treatment, were recruited.
    Summary · context
    Eight of the patients had been treated by surgery alone (Group A) and 11 had received primary or postoperative irradiation (Group B).
    Summary · context
    At the final visit hexarelin 1.5 mcg/kg was administered as an intravenous bolus at t = 0.
  2. 02HumanNon-randomized trialEfficacy outcome

    In acromegalic patients treated with irradiation, 5 of 11 had a GH response below 2 mU/l after hexarelin.

    In plain wordsIn treated acromegaly patients who had irradiation, 5 of 11 had almost no growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    MixedGH increment below 2 mU/l after hexarelin, group B
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 mcg/kg · intravenous bolusAs given in this study (human).

    Measurements

    GH increment after hexarelin
    < 2 mU/l
    Group B

    Source sentences

    Summary
    In group B only 4/11 achieved a DeltaGHHEX > 20 mU/l, 5/11 producing a response of < 2 mU/l.
    3 context sentences
    Summary · context
    Nineteen acromegalic patients, in whom mean serum GH levels below 5 mU/l have been achieved through treatment, were recruited.
    Summary · context
    Eight of the patients had been treated by surgery alone (Group A) and 11 had received primary or postoperative irradiation (Group B).
    Summary · context
    At the final visit hexarelin 1.5 mcg/kg was administered as an intravenous bolus at t = 0.
  3. 03HumanNon-randomized trialEfficacy outcome

    In acromegalic patients treated by surgery alone, hexarelin raised serum GH by more than 20 mU/l in all patients.

    In plain wordsIn treated acromegaly patients who had surgery alone, hexarelin raised growth hormone clearly in every patient.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH increment after hexarelin, group A
    Study

    n = 8

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 mcg/kg · intravenous bolusAs given in this study (human).

    Measurements

    GH increment after hexarelin
    > 20 mU/l
    Group A

    Source sentences

    Summary
    All patients in group A showed an increment in serum GH following hexarelin (DeltaGHHEX) > 20 mU/l
    3 context sentences
    Summary · context
    Nineteen acromegalic patients, in whom mean serum GH levels below 5 mU/l have been achieved through treatment, were recruited.
    Summary · context
    Eight of the patients had been treated by surgery alone (Group A) and 11 had received primary or postoperative irradiation (Group B).
    Summary · context
    At the final visit hexarelin 1.5 mcg/kg was administered as an intravenous bolus at t = 0.
  4. 04HumanNon-randomized trialOther

    Four of five patients with a hexarelin GH increment below 2 mU/l also had mean 24-h GH below 0.5 mU/l and IGF-I SDS below +0.5.

    In plain wordsMost patients with almost no response to hexarelin also had low growth hormone over 24 hours and low IGF-I.

    Peptide
    Hexarelin
    Outcome
    Not applicableLow hexarelin response and low basal GH and IGF-I
    Study

    n = 5

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 mcg/kg · intravenous bolusAs given in this study (human).

    Measurements

    Mean 24-h GH
    < 0.5 mU/l
    Patients with hexarelin response <2 mU/l

    Source sentences

    Summary
    Four of the five patients with a DeltaGHHEX < 2 mU/l were also demonstrated to have a mean 24-h GH of < 0.5 mU/l and serum IGF-I SDS < + 0.5.
    3 context sentences
    Summary · context
    Nineteen acromegalic patients, in whom mean serum GH levels below 5 mU/l have been achieved through treatment, were recruited.
    Summary · context
    Eight of the patients had been treated by surgery alone (Group A) and 11 had received primary or postoperative irradiation (Group B).
    Summary · context
    At the final visit hexarelin 1.5 mcg/kg was administered as an intravenous bolus at t = 0.
  5. 05HumanNon-randomized trialOther

    All four Group B patients with a hexarelin GH increment above 20 mU/l had an absent or minimal GH response to arginine.

    In plain wordsIn four irradiated patients who responded to hexarelin, the growth hormone response to arginine was absent or very small.

    Peptide
    Hexarelin
    Outcome
    Not applicableGH response to arginine in group B hexarelin responders
    Study

    n = 4

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.5 mcg/kg · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    All four patients in Group B who achieved a DeltaGHHEX > 20 mU/l, were observed to show an absent or minimal GH response to arginine.
    3 context sentences
    Summary · context
    Nineteen acromegalic patients, in whom mean serum GH levels below 5 mU/l have been achieved through treatment, were recruited.
    Summary · context
    Eight of the patients had been treated by surgery alone (Group A) and 11 had received primary or postoperative irradiation (Group B).
    Summary · context
    At the final visit hexarelin 1.5 mcg/kg was administered as an intravenous bolus at t = 0.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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