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Study · Animal study (in vivo) · rat · 2001

2 results

Penile erection induced by EP 80661 and other hexarelin peptide analogues: involvement of paraventricular nitric oxide.

Melis MR, Succu S, Spano MS, Torsello A, Locatelli V, Muller EE, Deghenghi R, Argiolas A

European journal of pharmacology1 Jan 2001Cited by 13 (Europe PMC)

PMID11164389 (opens in a new tab)DOI10.1016/s0014-2999(00)00929-8 (opens in a new tab)PepBankPUB-11164389
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, hexarelin at 1 microg did not induce penile erection, unlike the EP peptide analogues.

    In plain wordsIn male rats, hexarelin did not cause penile erection, while its related EP peptides did.

    Peptide
    Hexarelin
    Outcome
    No significant changePenile erection
    Study

    ratn: not reported in source

    Male rats, paraventricular nucleus microdialysis
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    1 microgAs given in this study (rat).

    Source sentences

    Summary
    In contrast, hexarelin (1 microg) was ineffective on either penile erection or paraventricular NO(2)(-) and NO(3)(-).
    1 context sentence
    Summary · context
    on the concentration of NO(2)(-) and NO(3)(-) in the paraventricular dialysate was studied in male rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, hexarelin at 1 microg did not change NO2- and NO3- levels in the paraventricular dialysate.

    In plain wordsIn male rats, hexarelin did not change nitric oxide breakdown products in a brain area, unlike its related EP peptides.

    Peptide
    Hexarelin
    Outcome
    No significant changeParaventricular NO2- and NO3- concentration
    Study

    ratn: not reported in source

    Male rats, paraventricular nucleus microdialysis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 microgAs given in this study (rat).

    Source sentences

    Summary
    In contrast, hexarelin (1 microg) was ineffective on either penile erection or paraventricular NO(2)(-) and NO(3)(-).
    1 context sentence
    Summary · context
    on the concentration of NO(2)(-) and NO(3)(-) in the paraventricular dialysate was studied in male rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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