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Study · In vitro (cells) · 2001

6 results

Bone marrow endothelial cells secrete thymosin beta4 and AcSDKP.

Huang WQ, Wang QR

Experimental hematology1 Jan 2001Cited by 34 (Europe PMC)

PMID11164101 (opens in a new tab)DOI10.1016/s0301-472x(00)00634-2 (opens in a new tab)PepBankPUB-11164101
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    Thymosin beta4 had a dose-dependent inhibitory effect on the growth of CFU-GM hematopoietic colonies in vitro.

    In plain wordsIn cells, thymosin beta4 slowed the growth of blood-forming cell colonies, and the effect grew with the dose.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCFU-GM growth with thymosin beta4
    Study

    n: not reported in source

    CFU-GM colony assay of hematopoietic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10(-11) approximately 10(-7)mol/LAs given in this study.

    Source sentences

    Summary
    Tbeta4 (10(-11) approximately 10(-7)mol/L) and AcSDKP (10(-11) approximately 10(-5)mol/L) had dose-dependent inhibitory effects on the growth of CFU-GM
    1 context sentence
    Summary · context
    Murine bone marrow endothelial cells (mBMECs) were cultured in serum-free conditioned medium.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02LabEndogenous levelIn vitro (cells)Mechanism

    Murine bone marrow endothelial cells expressed thymosin beta4 mRNA.

    In plain wordsIn mouse cells, bone marrow blood-vessel cells made their own thymosin beta4 mRNA.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin beta4 mRNA expression in bone marrow endothelial cells
    Study

    mousen: not reported in source

    murine bone marrow endothelial cells (mBMECs)
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    mBMECs expressed Tbeta4 mRNA.
    1 context sentence
    Summary · context
    Murine bone marrow endothelial cells (mBMECs) were cultured in serum-free conditioned medium.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 03LabEndogenous levelIn vitro (cells)Mechanism

    Thymosin beta4 was detected in the lysate and the conditioned medium of murine bone marrow endothelial cells.

    In plain wordsIn mouse cells, bone marrow blood-vessel cells held and released their own thymosin beta4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin beta4 detection in cell lysate and conditioned medium
    Study

    mousen: not reported in source

    murine bone marrow endothelial cells (mBMECs)
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    In EC lysate and mBMEC-CM, Tbeta4 and AcSDKP were detected.
    1 context sentence
    Summary · context
    Murine bone marrow endothelial cells (mBMECs) were cultured in serum-free conditioned medium.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 04LabEndogenous levelIn vitro (cells)Mechanism

    In lysate of murine bone marrow endothelial cells, adding protease inhibitors significantly increased the thymosin beta4 concentration.

    In plain wordsIn mouse cells, protease inhibitors raised the level of the cells' own thymosin beta4 in the cell extract.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta4 concentration in lysate after protease inhibitors
    Study

    mousen: not reported in source

    murine bone marrow endothelial cells (mBMECs)
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    After adding protease inhibitors, the concentration of Tbeta4 in EC lysate increased significantly, while the concentration of AcSDKP decreased
    1 context sentence
    Summary · context
    Murine bone marrow endothelial cells (mBMECs) were cultured in serum-free conditioned medium.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 05LabEndogenous levelIn vitro (cells)Mechanism

    Bone marrow endothelial cells expressed and secreted thymosin beta4, which was found in the 3-10 kD component of the conditioned medium.

    In plain wordsIn mouse cells, bone marrow blood-vessel cells released their own thymosin beta4 into the culture medium.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableSecretion and size fraction of thymosin beta4
    Study

    mousen: not reported in source

    murine bone marrow endothelial cells (mBMECs)
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    BMECs express and secrete Tbeta4 and AcSDKP.
    2 context sentences
    Summary · context
    Tbeta4 exists in the 3-10 kD component of mBMEC-CM, while AcSDKP exists in the <3 kD component of ECCM.
    Summary · context
    Murine bone marrow endothelial cells (mBMECs) were cultured in serum-free conditioned medium.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    Conditioned medium of mBMECs (3-10 kD component) had no effect on the formation of CFU-GM colonies.

    In plain wordsIn cells, the 3-10 kD part of the culture medium did not change colony formation by blood-forming cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEffect of 3-10 kD conditioned medium on CFU-GM formation
    Study

    mousen: not reported in source

    murine bone marrow endothelial cells (mBMECs)
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    mBMEC-CM (mw 3-10 kD) had no effect on the formation of CFU-GM.
    1 context sentence
    Summary · context
    Murine bone marrow endothelial cells (mBMECs) were cultured in serum-free conditioned medium.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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