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Study · Animal study (in vivo) · rat · 2000

8 results

The effects of a continuous infusion of hexarelin on pulsatile growth hormone release, growth axis and galanin gene expression and on the response of the growth axis to growth hormone-releasing hormone.

Conley LK, Brogan RS, Giustina A, Wehrenberg WB

Pituitary1 May 2000

PMID11081146 (opens in a new tab)DOI10.1023/a:1009957015563 (opens in a new tab)PepBankPUB-11081146
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious adult male rats, plasma GH peaked within 15 minutes of starting a hexarelin infusion and returned to baseline by 60 minutes.

    In plain wordsIn rats, hexarelin infusion raised growth hormone within 15 minutes, and it was back to baseline by 60 minutes.

    Peptide
    Hexarelin
    Outcome
    IncreasePlasma GH during hexarelin infusion
    Study

    ratn: not reported in source

    conscious adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    Plasma GH concentrations peaked within 15 minutes after the initiation of Hexarelin infusion, but returned to baseline levels by 60 minutes.
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious adult male rats, a 6-hour hexarelin infusion did not significantly change any analysed parameter of pulsatile GH release versus saline.

    In plain wordsIn rats, a 6-hour hexarelin infusion did not change the pulses of growth hormone release compared with saline.

    Peptide
    Hexarelin
    Outcome
    No significant changePulsatile GH release parameters
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    No significant differences between Hexarelin and saline infused rats were noted for any of the parameters of pulsatile GH release analyzed.
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious adult male rats, after a 6-hour hexarelin infusion the GH response to GHRH was greater than after saline.

    In plain wordsIn rats, after a 6-hour hexarelin infusion, growth hormone responded more strongly to GHRH than after saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH responsiveness to GHRH after hexarelin infusion
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Measurements

    Delta GH
    57 ng/ml
    hexarelin infused
    Delta GH
    21 ng/ml
    saline infused

    Source sentences

    Summary
    However, following a 6 hour infusion, rats treated with Hexarelin demonstrated a greater GH responsiveness to GHRH (delta GH: 57 +/- 16 ng/ml for Hexarelin infused; 21 +/- 7 ng/ml for saline infused; p < 0.05).
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hexarelin infusion decreased hypothalamic GHRH mRNA content compared with saline.

    In plain wordsIn rats, hexarelin infusion lowered GHRH gene activity in the brain compared with saline.

    Peptide
    Hexarelin
    Outcome
    DecreaseHypothalamic GHRH mRNA content
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    the rats infused with Hexarelin demonstrated decreased GHRH
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hexarelin infusion increased hypothalamic galanin mRNA content compared with saline.

    In plain wordsIn rats, hexarelin infusion raised galanin gene activity in the brain compared with saline.

    Peptide
    Hexarelin
    Outcome
    IncreaseHypothalamic galanin mRNA content
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    increased hypothalamic galanin mRNA contents as compared to the saline infused rats, while hypothalamic somatostatin and pituitary GH mRNA contents appeared unchanged.
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hexarelin infusion left hypothalamic somatostatin mRNA content unchanged compared with saline.

    In plain wordsIn rats, hexarelin infusion did not change somatostatin gene activity in the brain.

    Peptide
    Hexarelin
    Outcome
    No significant changeHypothalamic somatostatin mRNA content
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    while hypothalamic somatostatin and pituitary GH mRNA contents appeared unchanged.
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hexarelin infusion left pituitary GH mRNA content unchanged compared with saline.

    In plain wordsIn rats, hexarelin infusion did not change growth hormone gene activity in the pituitary gland.

    Peptide
    Hexarelin
    Outcome
    No significant changePituitary GH mRNA content
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    while hypothalamic somatostatin and pituitary GH mRNA contents appeared unchanged.
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hexarelin infusion lowered pituitary galanin mRNA content compared with saline.

    In plain wordsIn rats, hexarelin infusion lowered galanin gene activity in the pituitary gland compared with saline.

    Peptide
    Hexarelin
    Outcome
    DecreasePituitary galanin mRNA content
    Study

    ratn: not reported in source

    conscious adult male rats
    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms/hour · 6 hoursAs given in this study (rat).

    Source sentences

    Summary
    Rats infused with Hexarelin had lower pituitary galanin mRNA content than did the rats which were infused with saline.
    1 context sentence
    Summary · context
    The effect of a 6 hour continuous infusion of Hexarelin (100 micrograms/hour) on GH peak frequency, amplitude and duration, GH trough concentrations, the interval between successive peaks and the pituitary responsiveness to GHRH, as well as GH axis and galanin mRNA contents, were examined in conscious adult male rats.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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