Interaction between glucagon and hexarelin, a peptidyl GH secretagogue, on somatotroph and corticotroph secretion in humans.

Arvat E, Maccagno B, Ramunni J, Giordano R, Broglio F, Gianotti L, Maccario M, Camanni F, Ghigo E

European journal of endocrinology1 Nov 2000Cited by 15 (Europe PMC)

PMID11078983DOI10.1530/eje.0.1430601PepBankPUB-11078983

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In six healthy young women, hexarelin induced a marked increase in GH levels.
In plain wordsIn six healthy young women, hexarelin caused a marked rise in growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
HEX induced a marked increase in GH levels (55.7+/-19.8 vs 3. 7+/-1.9 microg/l, P<0.005) and also significant ACTH (5.7+/-1.1 vs 3. 4+/-0.6 pmol/l, P<0.01) and cortisol (400.2+/-31.4 vs 363.4+/-32.2 nmol/l, P<0.05) responses.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
Report a problemFND-1107898301
02HumanNon-randomized trialEfficacy outcome
In six healthy young women, hexarelin induced a significant ACTH increase (peak 5.7 versus baseline 3.4 pmol/l).
In plain wordsIn six healthy young women, hexarelin caused a significant rise in ACTH.
Peptide
Hexarelin
Outcome
IncreaseACTH response to hexarelin
Study
n = 6
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
HEX induced a marked increase in GH levels (55.7+/-19.8 vs 3. 7+/-1.9 microg/l, P<0.005) and also significant ACTH (5.7+/-1.1 vs 3. 4+/-0.6 pmol/l, P<0.01) and cortisol (400.2+/-31.4 vs 363.4+/-32.2 nmol/l, P<0.05) responses.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
Report a problemFND-1107898302
03HumanNon-randomized trialEfficacy outcome
In six healthy young women, hexarelin induced a significant cortisol increase (peak 400.2 versus baseline 363.4 nmol/l).
In plain wordsIn six healthy young women, hexarelin caused a significant rise in cortisol.
Peptide
Hexarelin
Outcome
IncreaseCortisol response to hexarelin
Study
n = 6
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
HEX induced a marked increase in GH levels (55.7+/-19.8 vs 3. 7+/-1.9 microg/l, P<0.005) and also significant ACTH (5.7+/-1.1 vs 3. 4+/-0.6 pmol/l, P<0.01) and cortisol (400.2+/-31.4 vs 363.4+/-32.2 nmol/l, P<0.05) responses.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
Report a problemFND-1107898303
04HumanNon-randomized trialEfficacy outcome
In six healthy young women, the GH area under the curve after hexarelin was higher than after glucagon.
In plain wordsIn six healthy young women, hexarelin released more growth hormone than glucagon did.
Peptide
Hexarelin
Outcome
IncreaseGH AUC after hexarelin versus glucagon
Study
n = 6
Comparator
Glucagon 0.017 mg/kg i.m.
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
The GH area under the curve (AUC) after HEX was clearly higher than after GLU (1637.3+/-494.0 vs 479.1+/-115. 7 microg/l/120 min, P<0.04) while HEX and GLU coadministration had a true synergistic effect on GH release (3243.8+/-687.5 microg/l/120 min, P<0.02).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
Report a problemFND-1107898304
05HumanNon-randomized trialEfficacy outcome
In six healthy young women, the ACTH area under the curve after hexarelin was lower than after glucagon.
In plain wordsIn six healthy young women, hexarelin raised ACTH less than glucagon did.
Peptide
Hexarelin
Outcome
DecreaseACTH AUC after hexarelin versus glucagon
Study
n = 6
Comparator
Glucagon 0.017 mg/kg i.m.
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
The ACTH and cortisol AUCs after HEX were lower (P<0. 02) than those after GLU (208.3+/-41.3 vs 426.3+/-80.9 pmol/l/120 min and 18 874.5+/-1626.1 vs 28 338.5+/-2430.7 nmol/l/120 min respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
Report a problemFND-1107898305
06HumanNon-randomized trialEfficacy outcome
In six healthy young women, the cortisol area under the curve after hexarelin was lower than after glucagon.
In plain wordsIn six healthy young women, hexarelin raised cortisol less than glucagon did.
Peptide
Hexarelin
Outcome
DecreaseCortisol AUC after hexarelin versus glucagon
Study
n = 6
Comparator
Glucagon 0.017 mg/kg i.m.
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2.0 microg/kg · intravenousAs given in this study (human).
Source sentences
Summary
The ACTH and cortisol AUCs after HEX were lower (P<0. 02) than those after GLU (208.3+/-41.3 vs 426.3+/-80.9 pmol/l/120 min and 18 874.5+/-1626.1 vs 28 338.5+/-2430.7 nmol/l/120 min respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
Report a problemFND-1107898306

Studies that did not test the peptide alone3

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

07HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In six healthy young women, coadministration of hexarelin and glucagon had a true synergistic effect on GH release.
In plain wordsIn six healthy young women, hexarelin and glucagon given together released more growth hormone than expected from each alone.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin plus glucagon
Study
n = 6
Comparator
Hexarelin alone and glucagon alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
while HEX and GLU coadministration had a true synergistic effect on GH release (3243.8+/-687.5 microg/l/120 min, P<0.02).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1107898307
08HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In six healthy young women, the combined hexarelin and glucagon regimen had a less than additive effect on ACTH secretion.
In plain wordsIn six healthy young women, hexarelin and glucagon together raised ACTH less than the sum of each alone.
Peptide
Hexarelin
Outcome
Not applicableACTH response to hexarelin plus glucagon
Study
n = 6
Comparator
Hexarelin alone and glucagon alone
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
The combined administration of HEX and GLU had an effect which was less than additive on both ACTH (564.02+/-76.5 pmol/l/120 min) and cortisol (35 424.6+/-5548.1 nmol/l/120 min) secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1107898308
09HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In six healthy young women, the combined hexarelin and glucagon regimen had a less than additive effect on cortisol secretion.
In plain wordsIn six healthy young women, hexarelin and glucagon together raised cortisol less than the sum of each alone.
Peptide
Hexarelin
Outcome
Not applicableCortisol response to hexarelin plus glucagon
Study
n = 6
Comparator
Hexarelin alone and glucagon alone
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
The combined administration of HEX and GLU had an effect which was less than additive on both ACTH (564.02+/-76.5 pmol/l/120 min) and cortisol (35 424.6+/-5548.1 nmol/l/120 min) secretion.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify the mechanisms underlying the stimulatory effects of both glucagon and GHS on somatotroph and corticotroph secretion, we studied the GH, ACTH and cortisol responses to glucagon (GLU, 0.017 mg/kg i.m.) and Hexarelin, a peptidyl GHS (HEX, 2.0 microg/kg i.v.) given alone or in combination in…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-1107898309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4NCT05206149

Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes

A.O.U. Città della Salute e della Scienzan = 101 Oct 2021 to 31 Dec 2021

Hypopituitarism

Trial page ClinicalTrials.govUpdated 25 Jan 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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